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Details

Stereochemistry ABSOLUTE
Molecular Formula C14H18FNO2
Molecular Weight 251.2966
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LUBAZODONE

SMILES

FC1=CC=C(OC[C@@H]2CNCCO2)C3=C1CCC3

InChI

InChIKey=HTODIQZHVCHVGM-JTQLQIEISA-N
InChI=1S/C14H18FNO2/c15-13-4-5-14(12-3-1-2-11(12)13)18-9-10-8-16-6-7-17-10/h4-5,10,16H,1-3,6-9H2/t10-/m0/s1

HIDE SMILES / InChI

Description

Lubazodone (YM 992) or (S)-2-[[(7-fluoro-4-indanyl)oxy]methyl]morpholine monohydrochloride, exhibited the biochemical profile of a selective serotonin (5-HT) reuptake inhibitor (SSRI) with 5-HT2A receptor antagonistic activity. It has been studied in the treatment of depression.

CNS Activity

CNS Active
3,913

Originator

Yamanouchi Pharmaceutical Co., Ltd.
2

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
5-hydroxytryptamine receptor 2A
69
Antagonist
2,778
 86.0 nM [Ki]
Sodium-dependent serotonin transporter
40
Inhibitor
8,297
 21.0 nM [Ki]

PubMed

ACTIVE MOIETY
Structure of LUBAZODONE
SALT/SOLVATE (PARENT)
Structure of LUBAZODONE HYDROCHLORIDE
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