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Details

Stereochemistry RACEMIC
Molecular Formula C20H33N2O.CH3O4S
Molecular Weight 428.586
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEXOCYCLIUM METHYLSULFATE

SMILES

COS([O-])(=O)=O.C[N+]1(C)CCN(CC(O)(C2CCCCC2)C3=CC=CC=C3)CC1

InChI

InChIKey=NSILVESQCSUIAJ-UHFFFAOYSA-M
InChI=1S/C20H33N2O.CH4O4S/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19;1-5-6(2,3)4/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1

HIDE SMILES / InChI
Hexocyclium is an old anticholinergic drug. Hexocyclium is an antimuscarinic. Hexocyclium in therapeutic doses produces a prolonged reduction of gastric acidity. It was used for the treatment of peptic ulcer. Hexocyclium is effective for the control of cramps and diarrhea in cases of irritable bowel syndrome.

Approval Year

Doses

Doses

DosePopulationAdverse events​
100 mg 2 times / day multiple, oral
Highest studied dose
Dose: 100 mg, 2 times / day
Route: oral
Route: multiple
Dose: 100 mg, 2 times / day
Sources: Page: p.18
unhealthy
n = 33
Health Status: unhealthy
Condition: Duodenal ulcer
Population Size: 33
Sources: Page: p.18
PubMed

PubMed

TitleDatePubMed
Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
1989 Apr
Patents

Sample Use Guides

Single oral doses of 25 mg and 50 mg
Route of Administration: Oral
In Vitro Use Guide
Acetylcholine-induced concentration-dependent tonic contraction of isolated rat fundus was concentration-dependently antagonized by hexocyclium (KB = 2.82 x 10(-10)M).
Name Type Language
HEXOCYCLIUM METHYLSULFATE
ORANGE BOOK   VANDF  
Common Name English
Hexocyclium metilsulfate [WHO-DD]
Common Name English
4-(.BETA.-CYCLOHEXYL-.BETA.-HYDROXYPHENETHYL)-1,1-DIMETHYLPIPERAZINUM METHYLSULFATE
Common Name English
4-(.BETA.-CYCLOHEXYL-.BETA.-HYDROXYPHENETHYL)-1,1-DIMETHYLPIPERAZINUM METHYLSULPHATE
Common Name English
HEXOCYCLIUM METHYLSULFATE [ORANGE BOOK]
Common Name English
HEXOCYCLIUM METHYLSULFATE [VANDF]
Common Name English
HEXOCYCLIUM METHYLSULPHATE
Common Name English
hexocyclium metilsulfate [INN]
Common Name English
HEXOCYCLIUM METILSULFATE [MART.]
Common Name English
HEXOCYCLIUM METHYL SULFATE [MI]
Common Name English
HEXOCYCLIUM METILSULFATE
INN   MART.   WHO-DD  
INN  
Official Name English
HEXOCYCLIUM METILSULPHATE
Common Name English
TRAL
Brand Name English
NSC-30256
Code English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Sat Dec 16 16:13:50 GMT 2023 , Edited by admin on Sat Dec 16 16:13:50 GMT 2023
Code System Code Type Description
PUBCHEM
101587
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PRIMARY
NSC
30256
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PRIMARY
EVMPD
SUB08040MIG
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PRIMARY
ECHA (EC/EINECS)
204-097-2
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PRIMARY
CAS
115-63-9
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ChEMBL
CHEMBL1201325
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EPA CompTox
DTXSID4023123
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SMS_ID
100000083980
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MESH
C015922
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MERCK INDEX
m6012
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PRIMARY Merck Index
DRUG BANK
DBSALT001391
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RXCUI
235430
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PRIMARY RxNorm
INN
672
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FDA UNII
84OPZ2Q0VB
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PRIMARY
NCI_THESAURUS
C65851
Created by admin on Sat Dec 16 16:13:50 GMT 2023 , Edited by admin on Sat Dec 16 16:13:50 GMT 2023
PRIMARY