IPENOXAZONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H34N2O2
Molecular Weight	358.5176
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)C[C@H]1[C@H](OC(=O)N1CCCN2CCCCCC2)C3=CC=CC=C3

InChI

InChIKey=DQNMZSIJHFEYTM-LEWJYISDSA-N

InChI=1S/C22H34N2O2/c1-18(2)17-20-21(19-11-6-5-7-12-19)26-22(25)24(20)16-10-15-23-13-8-3-4-9-14-23/h5-7,11-12,18,20-21H,3-4,8-10,13-17H2,1-2H3/t20-,21+/m0/s1

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Description
Sources: http://www.chemdrug.com/article/8/3285/16420167.html

Ipenoxazone (NC 1200) is a muscle relaxant that is under investigation (phase II) for the treatment of Alzheimer's Dementia, Cognition Disorders. It acts as an Ionotropic glutamate receptor antagonist.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate [NMDA] receptor 125 Target ID: CHEMBL2094124 Sources: http://www.ncbi.nlm.nih.gov/pubmed/15277038	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Alzheimer's dementia 6 Sources: http://www.chemdrug.com/article/8/3285/16420167.html	Primary		Phase II 1132	Unknown Approved Use Unknown
Cognition disorders 21 Sources: http://www.chemdrug.com/article/8/3285/16420167.html	Primary		Phase II 1132	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
Compound Cloud	13713369
Compound Cloud	65882
MuseChem	M008767	https://www.musechem.com/product/M008767.html
Toronto Research Chemicals	I739445	https://www.trc-canada.com/product-detail/?CatNum=I739445

PubMed

Title	Date	PubMed
Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.	1988	3345898

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

NC-1200 (IPENOXAZONE) acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67

Name

Type

Language

IPENOXAZONE

Official Name

English

MLV6976

Code

English

NC1200

Code

English

NC-1200

Code

English

MLV-6976

Code

English

ipenoxazone [INN]

Common Name

English

(+)-(4S,5R)-3-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPYL)-4-ISOBUTYL-5-PHENYL-2-OXAZOLIDINONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1509