Stereochemistry | ACHIRAL |
Molecular Formula | C8H5NO2 |
Molecular Weight | 147.1308 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NC2=C(C=CC=C2)C1=O
InChI
InChIKey=JXDYKVIHCLTXOP-UHFFFAOYSA-N
InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
Isatin (1H-indole-2,3-dione) is a naturally occurring
heterocycle that was first synthesised by Erdmann and
Laurent in 1840. Isatin possesses a wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activities and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. Isatin is an endogenous monoamine oxidase (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes.
CNS Activity
Originator
Approval Year
Sample Use Guides
Rats: Isatin (100 mg/kg, i.p.) inhibited APO-induced rotations of Parkinsonian rats to 39.1+/-3.7% of the control (n=12), while it had no apparent effects on electrical stimuli-induced DA release either in normal rats or in model rats. In addition, the content of 5-hydroxytryptamine but not DA was increased in both normal rats and model rats after isatin (100 mg/kg, i.p.) was administered.
Route of Administration:
Intraperitoneal