SULFASUCCINAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12N2O5S
Molecular Weight	272.278
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC=C(NC(=O)CCC(O)=O)C=C1

InChI

InChIKey=RXXXPZYBZLDQKP-UHFFFAOYSA-N

InChI=1S/C10H12N2O5S/c11-18(16,17)8-3-1-7(2-4-8)12-9(13)5-6-10(14)15/h1-4H,5-6H2,(H,12,13)(H,14,15)(H2,11,16,17)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27144971 | https://www.google.ru/url?sa=t&rct=j&q=&esrc=s&source=web&cd=13&ved=0ahUKEwjtg4eg0tzYAhXrA5oKHZaADV84ChAWCDIwAg&url=http%3A%2F%2Fwww.drugfuture.com%2Fmt%2Fsulfanilamide.pdf&usg=AOvVaw1FJc_CG13ZxVGU40V0ofoh

Sulfasuccinamide is a sulfonamide antibacterial with properties similar to those of sulfamethoxazole. It has been applied topically in the treatment of local infections of the ear, nose, and throat. It has also been given as the sodium salt. Sulfasuccinamide is a carbonic anhydrase inhibitor.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Carbonic anhydrase XII 30 Target ID: CHEMBL3242 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27144971	Inhibitor 8297	0.52 nM [Ki]
Carbonic anhydrase XIV 22 Target ID: CHEMBL3510 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27144971	Inhibitor 8297	6.1 nM [Ki]
Carbonic anhydrase IX 35 Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27144971	Inhibitor 8297	12.8 nM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Infections of the ear, nose, and throat 5 Sources: http://sante.lefigaro.fr/medicaments/3272644-rhinatp-sol-nas-fl-10ml	Primary		Not Provided 504	Sulfasuccinamide Approved Use Applied topically in the treatment of local infections of the ear, nose, and throat.

PubMed

Title	Date	PubMed
PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.	2016 May 26	27144971

Sample Use Guides

In Vivo Use Guide

Nasal solution

Route of Administration: Nasal

In Vitro Use Guide

Sulfasuccinamide inhibited human recombinant carbonic anhydrase 12 with Ki value of 0.52 nM. Sulfasuccinamide decreased tumor cell viability of colon HT-29 cells in a concentration-dependent manner (0.01 - 1 mM).

Name

Type

Language

SULFASUCCINAMIDE

Official Name

English

NSC-30143

Code

English

sulfasuccinamide [INN]

Common Name

English

Sulfasuccinamide [WHO-DD]

Common Name

English

SULFASUCCINAMIDE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29739