MEDORINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H8N2O
Molecular Weight	160.1726
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC=CC2=C1C=CC(=O)N2

InChI

InChIKey=OCCZJXAHSUCJSA-UHFFFAOYSA-N

InChI=1S/C9H8N2O/c1-6-7-2-3-9(12)11-8(7)4-5-10-6/h2-5H,1H3,(H,11,12)

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Description
Sources: https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.430210203 | https://www.ncbi.nlm.nih.gov/pubmed/2116683 | https://www.ncbi.nlm.nih.gov/pubmed/1336055

Medorinone is an inhibitor of cAMP phosphodiesterase activity. Inhibition of cAMP phosphodiesterase by medorinone in cardiac and vascular smooth muscle is a mechanism by which this agent produces both positive cardiac inotropy and vascular smooth muscle relaxation. It inhibits platelet aggregation.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Phosphodiesterase 3 60 Target ID: CHEMBL2094125 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1336055	Inhibitor 8297		0.55 µM [IC50]

PubMed

Title	Date	PubMed
A comparison of the effects of three positive inotropic agents (amrinone, milrinone and medorinone) on platelet aggregation in human whole blood.	1990 Mar 15	2116683
Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones.	1992 Dec 25	1336055
Electric field mapping and structure-activity relationship for cardiotonic activities of medorinone and some of its analogs.	1997 Oct	9594423

Patents

Name

Type

Language

MEDORINONE

Official Name

English

1,6-NAPHTHYRIDIN-2(1H)-ONE, 5-METHYL-

Systematic Name

English

WIN-49016

Code

English

WIN 49,016

Code

English

WIN-49,016

Code

English

MEDORINONE [USAN]

Common Name

English

medorinone [INN]

Common Name

English

5-Methyl-1,6-naphthyridin-2(1H)-one

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744