U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C5H7N3O2S.C4H9NO
Molecular Weight 260.313
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIOTRIAZOLINE

SMILES

C1COCCN1.CC2=NN=C(N2)SCC(O)=O

InChI

InChIKey=MSYQJZMDTZWNQZ-UHFFFAOYSA-N
InChI=1S/C5H7N3O2S.C4H9NO/c1-3-6-5(8-7-3)11-2-4(9)10;1-3-6-4-2-5-1/h2H2,1H3,(H,9,10)(H,6,7,8);5H,1-4H2

HIDE SMILES / InChI
Tiazotic acid is an antioxidant. As tiazotic acid morpholinium salt it is marketed under the brand names Thiotriazoline, Tiokor among others in Russia, Ukraine, Uzbekistan as the treatment of ischemic heart diseases. It is proposed to be a hepatoprotective, wound-healing and antiviral agent. A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy. The study assessed the efficacy of the two drugs on total exercise duration, time to 1-mm ST segment depression, the number of angina attacks and nitroglycerin tablets consumed amount. Both drugs have demonstrated clinical efficacy equal for all primary and secondary endpoints. Thiotriazoline was also used for the he correction of hepatotoxicity during combined chemoradiotherapy for cancer patients.

Approval Year

PubMed

PubMed

TitleDatePubMed
Two polymorphs of morpholin-4-ium 2-(5-methyl-1H-1,2,4-triazol-3-ylsulfanyl)acetate.
2009 Jan
Patents

Sample Use Guides

A comparative international multicenter randomized trial, assessed anti-anginal anti ischemic efficacy and safety of Trimetazidine (60 mg/d) and Thiotriazoline (600 mg/d) in symptomatic patients with chronic ischemic heart disease receiving the first line therapy.
Route of Administration: Oral
Name Type Language
THIOTRIAZOLINE
WHO-DD  
Common Name English
Thiotriazoline [WHO-DD]
Common Name English
ACETIC ACID, 2-((3-METHYL-1H-1,2,4-TRIAZOL-5-YL)THIO)-, COMPD. WITH MORPHOLINE (1:1)
Systematic Name English
ACETIC ACID, ((3-METHYL-1H-1,2,4-TRIAZOL-5-YL)THIO)-, COMPD. WITH MORPHOLINE (1:1)
Systematic Name English
((3-METHYL-1H-1,2,4-TRIAZOL-5-YL)SULFANYL)ACETIC ACID - MORPHOLINE (1:1)
Systematic Name English
MORPHOLINE, ((5-METHYL-1H-1,2,4-TRIAZOL-3-YL)THIO)ACETATE
Systematic Name English
ACETIC ACID, ((5-METHYL-1H-1,2,4-TRIAZOL-3-YL)THIO)-, COMPD. WITH MORPHOLINE (1:1)
Systematic Name English
THIOTRIAZOLIN
Common Name English
MORPHOLINE 5-METHYL-1,2,4-TRIAZOLINE-5-THIOACETATE
Common Name English
TIOTRIAZOLIN
Common Name English
MORPHOLIN-4-IUM 2-(5-METHYL-1H-1,2,4-TRIAZOL-3-YLSULFANYL) ACETATE
Systematic Name English
Code System Code Type Description
PUBCHEM
15411619
Created by admin on Sat Dec 16 08:45:58 GMT 2023 , Edited by admin on Sat Dec 16 08:45:58 GMT 2023
PRIMARY
CAS
357172-63-5
Created by admin on Sat Dec 16 08:45:58 GMT 2023 , Edited by admin on Sat Dec 16 08:45:58 GMT 2023
PRIMARY
SMS_ID
100000124425
Created by admin on Sat Dec 16 08:45:58 GMT 2023 , Edited by admin on Sat Dec 16 08:45:58 GMT 2023
PRIMARY
EVMPD
SUB32102
Created by admin on Sat Dec 16 08:45:58 GMT 2023 , Edited by admin on Sat Dec 16 08:45:58 GMT 2023
PRIMARY
FDA UNII
80FD3I7462
Created by admin on Sat Dec 16 08:45:58 GMT 2023 , Edited by admin on Sat Dec 16 08:45:58 GMT 2023
PRIMARY