U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Disomotide is an oligopeptide in phase III clinical development for the treatment of melanoma. Vaccination with the disomotide peptide has resulted in very high levels of circulating T cells that were capable of recognizing and killing melanoma cancer cells in vitro. In a single-group, phase 2 study, patients with metastatic melanoma were immunized with the disomotide peptide vaccine in Montanide ISA-51 (incomplete Freund’s adjuvant), followed by high-dose interleukin-2, leading to objective clinical responses in 13 of 31 patients. Randomized study showed the clinical benefit of a vaccine in the treatment of patients with measurable metastatic melanoma. Patients receiving the disomotide with interleukin-2 were more than twice as likely to have a clinical response as those receiving interleukin-2 alone.

Approval Year

PubMed

PubMed

TitleDatePubMed
Characterization of the class I-restricted gp100 melanoma peptide-stimulated primary immune response in tumor-free vaccine-draining lymph nodes and peripheral blood.
2009 Apr 1
gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma.
2011 Jun 2
Name Type Language
DISOMOTIDE
INN   USAN  
USAN   INN  
Official Name English
Disomotide [WHO-DD]
Common Name English
MPS-22
Code English
L-VALINE, L-ISOLEUCYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-L-GLUTAMINYL-L-VALYL-L-PROLYL-L-PHENYLALANYL-L-SERYL-
Common Name English
disomotide [INN]
Common Name English
DISOMOTIDE [USAN]
Common Name English
GP-100:209-217(210M) PEPTIDE
Common Name English
GP100:209-217(210M) PEPTIDE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1752
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL263429
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
PUBCHEM
657090
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
USAN
RR-78
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
NCI_THESAURUS
C76227
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
EPA CompTox
DTXSID50171158
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
FDA UNII
8028PPX4PM
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
INN
8694
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY
CAS
181477-43-0
Created by admin on Sat Dec 16 00:43:22 GMT 2023 , Edited by admin on Sat Dec 16 00:43:22 GMT 2023
PRIMARY