Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H15Cl2NO |
| Molecular Weight | 260.16 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1
InChI
InChIKey=VUNCGGHZBFQRPB-UHFFFAOYSA-N
InChI=1S/C12H15Cl2NO/c1-3-4-8(2)12(16)15-9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. | 2015-11-15 |
|
| Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway. | 2015-10-05 |
|
| Effects of Melatonin-Aided Therapy on the Glutathione Antioxidant System Activity and Liver Protection. | 2015-10 |
|
| Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. | 2015-09-17 |
|
| Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice. | 2015-06-25 |
|
| Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. | 2015-03-25 |
|
| Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat. | 2014-10 |
|
| Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents. | 2014-05 |
|
| Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study. | 2014-02 |
|
| Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach. | 2014-01-15 |
|
| Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice. | 2014-01 |
|
| Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol. | 2014 |
|
| Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013-12 |
|
| Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism. | 2013-12 |
|
| Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement. | 2013-10 |
|
| Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats. | 2013-05-23 |
|
| Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. | 2013-03 |
|
| Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats. | 2013-02-13 |
|
| Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. | 2013-01-25 |
|
| Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. | 2012-09 |
|
| Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat. | 2012-09 |
|
| Long-term administration of Silymarin augments proinflammatory mediators in the hippocampus of rats: evidence for antioxidant and pro-oxidant effects. | 2012-09 |
|
| Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis. | 2012-05 |
|
| Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity. | 2012-03 |
|
| Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis. | 2011-04-15 |
|
| Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. | 2011-03 |
|
| Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. | 2011-02-04 |
|
| Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. | 2011-01-10 |
|
| Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells. | 2010-12-05 |
|
| Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models. | 2010-12-05 |
|
| Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats. | 2010-12 |
|
| Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study. | 2010-09-01 |
|
| Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. | 2010-06-01 |
|
| Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles. | 2010-06 |
|
| Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. | 2010-03 |
|
| Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells. | 2009-03-18 |
|
| Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: involvement of inducible nitric oxide synthase and hemoxygenase-1. | 2009-02 |
|
| Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. | 2008-07 |
|
| Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats. | 2008-01 |
|
| Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. | 2008 |
|
| Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats. | 2007-12 |
|
| Protective effects of Cuscutae semen against dimethylnitrosamine-induced acute liver injury in Sprague-Dawley rats. | 2007-08 |
|
| Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. | 2007-08 |
|
| Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | 2007-04 |
|
| Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. | 2007-02 |
|
| Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis. | 2007-01 |
|
| Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. | 2006-11 |
|
| [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats]. | 2006-09-26 |
|
| Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. | 1997-09 |
|
| [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion]. | 1986-10 |
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SUBSTANCE RECORD
