Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C12H15Cl2NO |
| Molecular Weight | 260.16 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(C)C(=O)NC1=CC(Cl)=C(Cl)C=C1
InChI
InChIKey=VUNCGGHZBFQRPB-UHFFFAOYSA-N
InChI=1S/C12H15Cl2NO/c1-3-4-8(2)12(16)15-9-5-6-10(13)11(14)7-9/h5-8H,3-4H2,1-2H3,(H,15,16)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion]. | 1986 Oct |
|
| Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. | 1997 Sep |
|
| Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats. | 2006 May |
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| [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats]. | 2006 Sep 26 |
|
| Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride. | 2007 Aug |
|
| Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats. | 2007 Dec |
|
| Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice. | 2008 |
|
| Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats. | 2008 Jan |
|
| Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats. | 2008 Jul |
|
| Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models. | 2010 Dec 5 |
|
| Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study. | 2010 Sep 1 |
|
| Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice. | 2011 Feb 4 |
|
| Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity. | 2012 Mar |
|
| Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line. | 2012 Sep |
|
| Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat. | 2012 Sep |
|
| Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats. | 2013 Feb 13 |
|
| Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. | 2013 Jan 25 |
|
| Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats. | 2013 May 23 |
|
| Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study. | 2014 Feb |
|
| Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat. | 2014 Oct |
|
| Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice. | 2015 Jun 25 |
|
| Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats. | 2015 Nov 15 |
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m6603
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2533-89-3
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