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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H15F2NO2.ClH
Molecular Weight 279.711
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANIFAXINE HYDROCHLORIDE

SMILES

Cl.C[C@@H]1CO[C@](O)([C@H](C)N1)C2=CC(F)=CC(F)=C2

InChI

InChIKey=TWDNQLAJZYOSNV-FZHAGLAKSA-N
InChI=1S/C12H15F2NO2.ClH/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9;/h3-5,7-8,15-16H,6H2,1-2H3;1H/t7-,8+,12-;/m1./s1

HIDE SMILES / InChI

Description

Manifaxine (GW 320659) is a highly selective neuronal norepinephrine and dopamine re-uptake inhibitor. It has been in phase II clinical trials by GlaxoSmithKline for the treatment of attention deficit hyperactivity disorder and obesity. Manifaxine development has been discontinued.

CNS Activity

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review.
2010-10
Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects.
2005-12

Sample Use Guides

In Vivo Use Guide
a multicenter, open-label, dose-titration study of seven daily dose levels of manifaxine (GW 320659): 1.25, 2.5, 5, 7.5,10,12.5, and 15 mg.
Route of Administration: Unknown
Name Type Language
MANIFAXINE HYDROCHLORIDE
INN  
Official Name English
2-MORPHOLINOL, 2-(3,5-DIFLUOROPHENYL)-3,5-DIMETHYL-, HYDROCHLORIDE, (2S,3S,5R)-
Preferred Name English
2-MORPHOLINOL, 2-(3,5-DIFLUOROPHENYL)-3,5-DIMETHYL-, HYDROCHLORIDE, (2S-(2.ALPHA.,3.ALPHA.,5.ALPHA.))-
Systematic Name English
BW-1555U88
Code English
2-(3,5-DIFLUOROPHENYL)-3,5-DIMETHYL-(2S-(2A,3A,5A))-2-MORPHOLINOL HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
FDA UNII
7ULY06A77E
Created by admin on Mon Mar 31 18:12:09 GMT 2025 , Edited by admin on Mon Mar 31 18:12:09 GMT 2025
PRIMARY
CAS
135306-42-2
Created by admin on Mon Mar 31 18:12:09 GMT 2025 , Edited by admin on Mon Mar 31 18:12:09 GMT 2025
PRIMARY
PUBCHEM
9903808
Created by admin on Mon Mar 31 18:12:09 GMT 2025 , Edited by admin on Mon Mar 31 18:12:09 GMT 2025
PRIMARY
PARENT (SALT/SOLVATE)
Structure of MANIFAXINE
NIH
NCATS
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