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Details

Stereochemistry UNKNOWN
Molecular Formula C30H32ClN3O8
Molecular Weight 598.043
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CRONIDIPINE

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCC3COC4(CCN(CC4)C5=CC=C(Cl)C=C5)O3

InChI

InChIKey=CNIJVNPIIHWRRP-UHFFFAOYSA-N
InChI=1S/C30H32ClN3O8/c1-18-25(28(35)39-3)27(20-5-4-6-23(15-20)34(37)38)26(19(2)32-18)29(36)40-16-24-17-41-30(42-24)11-13-33(14-12-30)22-9-7-21(31)8-10-22/h4-10,15,24,27,32H,11-14,16-17H2,1-3H3

HIDE SMILES / InChI
Cronidipine (LF 2.0254) is a calcium channel blocker. LF 2.0254 inhibited in a time-dependent fashion K(+)- and Ca2(+)-induced contractions of rabbit aorta with respective IC50 of 2.7 nM and 1.7 nM. Cronidipine had a long-lasting antihypertensive action in spontaneously hypertensive rats and was able to decrease blood pressure and increase heart rate and plasma renin activity in hypertensive dogs.

Approval Year

PubMed

PubMed

TitleDatePubMed
Antihypertensive activity of a new calcium channel blocker LF 2.0254, in spontaneously hypertensive rats: a comparison with nifedipine and nicardipine.
1988 Sep-Oct
Patents

Patents

Name Type Language
CRONIDIPINE
INN  
INN  
Official Name English
cronidipine [INN]
Common Name English
(8-(P-CHLOROPHENYL)-1,4-DIOXA-8-AZASPIRO(4,5)DEC-2-YL)METHYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C333
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C81683
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
PRIMARY
PUBCHEM
65918
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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EVMPD
SUB06826MIG
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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DRUG BANK
DB09233
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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INN
6417
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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SMS_ID
100000083721
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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CAS
113759-50-5
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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FDA UNII
7TXJ9MY5V9
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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ChEMBL
CHEMBL2106056
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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EPA CompTox
DTXSID00921185
Created by admin on Fri Dec 15 17:26:45 GMT 2023 , Edited by admin on Fri Dec 15 17:26:45 GMT 2023
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