CRONIDIPINE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C30H32ClN3O8
Molecular Weight	598.043
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCC3COC4(CCN(CC4)C5=CC=C(Cl)C=C5)O3

InChI

InChIKey=CNIJVNPIIHWRRP-UHFFFAOYSA-N

InChI=1S/C30H32ClN3O8/c1-18-25(28(35)39-3)27(20-5-4-6-23(15-20)34(37)38)26(19(2)32-18)29(36)40-16-24-17-41-30(42-24)11-13-33(14-12-30)22-9-7-21(31)8-10-22/h4-10,15,24,27,32H,11-14,16-17H2,1-3H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2112508 | https://www.ncbi.nlm.nih.gov/pubmed/2977540

Cronidipine (LF 2.0254) is a calcium channel blocker. LF 2.0254 inhibited in a time-dependent fashion K(+)- and Ca2(+)-induced contractions of rabbit aorta with respective IC50 of 2.7 nM and 1.7 nM. Cronidipine had a long-lasting antihypertensive action in spontaneously hypertensive rats and was able to decrease blood pressure and increase heart rate and plasma renin activity in hypertensive dogs.

Approval Year

PubMed

Title	Date	PubMed
Antihypertensive activity of a new calcium channel blocker LF 2.0254, in spontaneously hypertensive rats: a comparison with nifedipine and nicardipine.	1988 Sep-Oct	2977540

Patents

Name

Type

Language

CRONIDIPINE

Official Name

English

cronidipine [INN]

Common Name

English

(8-(P-CHLOROPHENYL)-1,4-DIOXA-8-AZASPIRO(4,5)DEC-2-YL)METHYL METHYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333