Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C17H14O6 |
| Molecular Weight | 314.2895 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C([C@@H]3CCO[C@@H]3O2)C4=C1C5=C(C(=O)CC5)C(=O)O4
InChI
InChIKey=WWSYXEZEXMQWHT-WNWIJWBNSA-N
InChI=1S/C17H14O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h6,8,17H,2-5H2,1H3/t8-,17+/m0/s1
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21038701 | https://goo.gl/bx6rLb | https://www.ncbi.nlm.nih.gov/pubmed/27863407 | https://www.ncbi.nlm.nih.gov/pubmed/19699076
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/21038701 | https://goo.gl/bx6rLb | https://www.ncbi.nlm.nih.gov/pubmed/27863407 | https://www.ncbi.nlm.nih.gov/pubmed/19699076
Aflatoxin B2 is the dihydro derivative of aflatoxin B1, a naturally occurring mycotoxin and food contaminant that is a likely pathogen that causes hepatocellular carcinoma. Aflatoxin B2 induces mitochondria-mediated apoptosis via the production of reactive oxygen species (ROS) and promotion of the translocation of Bax and cytochrome c between mitochondria and the cytosol, triggering the formation of apoptosomes. Aflatoxin B2 also inhibited the phosphoinositide 3-kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) pathway by activating PI3K, Akt, and mTOR and inhibiting their phosphorylation, contributing to the pro-autophagic activity of Aflatoxin B2.
Approval Year
Sample Use Guides
The broilers were given 0 mg/kg/d (control), 0.2 mg/kg/d, 0.4 mg/kg/d, and 0.8 mg/kg/d AFB2 for 21 d.
Route of Administration:
Oral
The HepG2 cell line (American Type Culture Collection (ATCC) HB-8065) was cultured in Eagle’s minimal essential medium (EMEM) containing 10% (v/v) fetal bovine serum (FBS). Cells were seeded in a 24-well plate at a cell plating density of 105 cells per well. After reaching 80% confluency, the cells were serum-starved overnight in EMEM containing 1% FBS. Following serum starvation, the cells were treated with UV-treated aflatoxin (Aflatoxin B2, 0.46mkg/ml) samples for 24 h. Following sample treatment, the cell viability was assayed using XTT assay (ATCC, Manassas, VA) as per the manufacturer’s protocol.
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C029753
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DTXSID70222535
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SUBSTANCE RECORD
