Details
Stereochemistry | ACHIRAL |
Molecular Formula | 3Mg.O10Si4.2HO |
Molecular Weight | 379.2657 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[OH-].[Mg++].[Mg++].[Mg++].[O-][Si]12O[Si]3([O-])O[Si]([O-])(O1)O[Si]([O-])(O2)O3
InChI
InChIKey=QLQXSZZVUVMFHZ-UHFFFAOYSA-L
InChI=1S/3Mg.O10Si4.2H2O/c;;;1-11-5-12(2)8-13(3,6-11)10-14(4,7-11)9-12;;/h;;;;2*1H2/q3*+2;-4;;/p-2
Talcum powder is made from talc, a mineral made up mainly of the elements magnesium, silicon, and oxygen. As a powder, it absorbs moisture well and helps cut down on friction, making it useful for keeping skin dry and helping to prevent rashes. It is widely used in cosmetic products such as baby powder and adult body and facial powders, as well as in a number of other consumer products. The therapeutic action of talc instilled into the pleural cavity is believed to result from induction of an inflammatory reaction. This reaction promotes adherence of the visceral and parietal pleura, obliterating the pleural space and preventing reaccumulation of pleural fluid. Sterile Talc Powder, administered intrapleurally via chest tube, is indicated as a sclerosing agent to decrease the recurrence of malignant pleural effusions in symptomatic patients. The most often reported adverse experiences to intrapleurally-administered talc were fever and pain.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | SCLEROSOL Approved UseSclerosol® Intrapleural Aerosol, administered by aerosol during thoracoscopy or open thoracotomy, is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients. Launch Date1997 |
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
91595
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FDA ORPHAN DRUG |
106797
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FDA ORPHAN DRUG |
109297
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CODEX ALIMENTARIUS (GSFA) |
INS-553(III)
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JECFA EVALUATION |
INS-553(III)
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C854
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238-877-9
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10323
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m10438
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CHEMBL1200568
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C45678
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CONCEPT | Industrial Aid | ||
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7SEV7J4R1U
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D013627
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14807-96-6
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DB09511
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122173976
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7SEV7J4R1U
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SUB12603MIG
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TALC
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PRIMARY | Description. A white or almost white, very fine, homogeneous, unctuous powder; odourless. Solubility: Practically insoluble in water, dilute solutions of acids and alkalis, ethanol (~750 g/l) TS, and ether R. Category: Tablet and capsule lubricant; glidant; diluent. Storage: Talc should be kept in a well-closed container. Additional information: Talc adheres readily to the skin. Attention should be paid to its microbiological quality since it is of mineral origin. Definition: Talc is a powdered, natural hydrate of magnesium silicate that may contain variable proportions of aluminium and iron. | ||
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100000078762
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SUB20830
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830
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5190
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ACTIVE MOIETY