U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 3Mg.O10Si4.2HO
Molecular Weight 379.2657
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TALC

SMILES

[OH-].[OH-].[Mg++].[Mg++].[Mg++].[O-][Si]12O[Si]3([O-])O[Si]([O-])(O1)O[Si]([O-])(O2)O3

InChI

InChIKey=QLQXSZZVUVMFHZ-UHFFFAOYSA-L
InChI=1S/3Mg.O10Si4.2H2O/c;;;1-11-5-12(2)8-13(3,6-11)10-14(4,7-11)9-12;;/h;;;;2*1H2/q3*+2;-4;;/p-2

HIDE SMILES / InChI
Talcum powder is made from talc, a mineral made up mainly of the elements magnesium, silicon, and oxygen. As a powder, it absorbs moisture well and helps cut down on friction, making it useful for keeping skin dry and helping to prevent rashes. It is widely used in cosmetic products such as baby powder and adult body and facial powders, as well as in a number of other consumer products. The therapeutic action of talc instilled into the pleural cavity is believed to result from induction of an inflammatory reaction. This reaction promotes adherence of the visceral and parietal pleura, obliterating the pleural space and preventing reaccumulation of pleural fluid. Sterile Talc Powder, administered intrapleurally via chest tube, is indicated as a sclerosing agent to decrease the recurrence of malignant pleural effusions in symptomatic patients. The most often reported adverse experiences to intrapleurally-administered talc were fever and pain.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
SCLEROSOL

Approved Use

Sclerosol® Intrapleural Aerosol, administered by aerosol during thoracoscopy or open thoracotomy, is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients.

Launch Date

1997

Sample Use Guides

The recommended dose is 5 g, suspended in 50 ml to 100 ml 0.9% Sodium Chloride Injection, USP
Route of Administration: Intrapleural
Name Type Language
TALC
EP   FCC   HSDB   II   INCI   MI   ORANGE BOOK   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
E-553(III)
Code English
PULVIS TALCI
CHP  
Common Name English
TALC [EP IMPURITY]
Common Name English
TALC [INCI]
Common Name English
HUASHIFEN
Common Name English
TALC [JAN]
Common Name English
INS NO.553(III)
Code English
TALC [ORANGE BOOK]
Common Name English
TALC [II]
Common Name English
TALC POWDER
Common Name English
TALC [VANDF]
Common Name English
SCLEROSOL
Brand Name English
TALC [USP MONOGRAPH]
Common Name English
TALC [MI]
Common Name English
TALC [WHO-IP]
Common Name English
TALC [EP MONOGRAPH]
Common Name English
PURIFIED TALC [MART.]
Common Name English
PULVIS TALCI [CHP]
Common Name English
Talc [WHO-DD]
Common Name English
INS-553(III)
Code English
TALC [HSDB]
Common Name English
TALCUM [WHO-IP LATIN]
Common Name English
TALC [FCC]
Common Name English
STERITALC
Brand Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 91595
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
FDA ORPHAN DRUG 106797
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
FDA ORPHAN DRUG 109297
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-553(III)
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
JECFA EVALUATION INS-553(III)
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C854
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
ECHA (EC/EINECS)
238-877-9
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
RXCUI
10323
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY RxNorm
MERCK INDEX
m10438
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY Merck Index
ChEMBL
CHEMBL1200568
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
CONCEPT Industrial Aid
DAILYMED
7SEV7J4R1U
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
MESH
D013627
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
CAS
14807-96-6
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
DRUG BANK
DB09511
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
PUBCHEM
122173976
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
FDA UNII
7SEV7J4R1U
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
EVMPD
SUB12603MIG
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
TALC
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY Description. A white or almost white, very fine, homogeneous, unctuous powder; odourless. Solubility: Practically insoluble in water, dilute solutions of acids and alkalis, ethanol (~750 g/l) TS, and ether R. Category: Tablet and capsule lubricant; glidant; diluent. Storage: Talc should be kept in a well-closed container. Additional information: Talc adheres readily to the skin. Attention should be paid to its microbiological quality since it is of mineral origin. Definition: Talc is a powdered, natural hydrate of magnesium silicate that may contain variable proportions of aluminium and iron.
SMS_ID
100000078762
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
EVMPD
SUB20830
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
HSDB
830
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY
DRUG CENTRAL
5190
Created by admin on Fri Dec 15 16:21:50 GMT 2023 , Edited by admin on Fri Dec 15 16:21:50 GMT 2023
PRIMARY