U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
BioMarin Pharmaceutical developed vosoritide (previously known as BMN 111) for children with achondroplasia, the most common form of dwarfism. Achondroplasia is an inherited autosomal-dominant chondrodysplasia caused by a gain-of-function mutation in fibroblast-growth-factor-receptor 3 (FGFR3). Vosoritide has been granted orphan drug designation in both the U.S. and Europe, and this drug participated in phase III clinical trials in children with achondroplasia. Vosoritide mimics C-type natriuretic peptide (CNP) and acts as a key regulator of longitudinal bone growth by downregulating the mitogen-activated protein kinase pathway, which is activated because of a FGFR3 gain-of-function mutation.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Subcutaneous injection of 15 μg/kg of BMN 111 daily
Route of Administration: Other
Name Type Language
VOSORITIDE
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
VOSORITIDE [JAN]
Common Name English
PRO-GLY-GLN-GLU-HIS-PRO-ASN-ALA-ARG-LYS-TYR-LYS-GLY-ALA-ASN-LYS-LYS-GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS 23-39 DISULFIDE
Common Name English
vosoritide [INN]
Common Name English
VOSORITIDE [USAN]
Common Name English
Vosoritide [WHO-DD]
Common Name English
BMN-111
Code English
VOXZOGO
Brand Name English
MODIFIED RECOMBINANT HUMAN C-TYPE NATRIURETIC PEPTIDE (CNP)
Common Name English
BMN 111 [WHO-DD]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 386012
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
NCI_THESAURUS C307
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL3707276
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
PRIMARY
FDA UNII
7SE5582Q2P
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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DRUG BANK
DB11928
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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SMS_ID
100000181691
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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DAILYMED
7SE5582Q2P
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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USAN
DE-24
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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PUBCHEM
119058036
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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INN
10022
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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WIKIPEDIA
Vosoritide
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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RXCUI
2586354
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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EPA CompTox
DTXSID001032751
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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CAS
1480724-61-5
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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NCI_THESAURUS
C152918
Created by admin on Sat Dec 16 08:10:42 GMT 2023 , Edited by admin on Sat Dec 16 08:10:42 GMT 2023
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