Nocloprost at doses of 50 and 100 ugrams was ineffective, but at a dose of 200 ugrams it reduced the response to pentagastrin significantly and that to a peptone meal by 30-50% and abolished plasma gastrin response without affecting the rate of gastric emptying. Nocloprost given at a dose of 100 ugrams three times daily 30 min before the major meals (breakfast, lunch, and dinner) did not affect intragastric pH significantly as monitored by continuous intraluminal pH-metry. Nocloprost does not affect gastric acid secretion or intraluminal pH when applied at a dose (50-100 ugrams) that is gastroprotective and that is proposed for peptic ulcer therapy. A higher dose (200 ugrams) of nocloprost causes moderate gastric acid inhibition and suppression of plasma gastrin release without affecting gastric emptying or causing any side effects.

Nocloprost inhibited release of endogenous norepinephrine from rat isolated trachea with the potency value (the concentration producing 35% inhibition of norepinephrine release (half-maximal effect)) of 8 nmol/L.