ISOMETAMIDIUM CHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H26N7.Cl
Molecular Weight	496.006
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].CC[N+]1=C(C2=CC=CC=C2)C3=C(C=CC(N\N=N\C4=CC(=CC=C4)C(N)=N)=C3)C5=CC=C(N)C=C15

InChI

InChIKey=QNZJTSGALAVCLH-UHFFFAOYSA-N

InChI=1S/C28H25N7.ClH/c1-2-35-26-16-20(29)11-13-24(26)23-14-12-22(17-25(23)27(35)18-7-4-3-5-8-18)33-34-32-21-10-6-9-19(15-21)28(30)31;/h3-17,29H,2H2,1H3,(H4,30,31,32,33);1H

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/isometamidium-chloride.html | http://www.inchem.org/documents/jecfa/jecmono/v25je10.htm

ISOMETAMIDIUM (as a chloride salt) is widely used in tropical countries as an antiprotozoal agent to control animal trypanosomiasis. It is used principally in cattle but also in sheep, goats, buffalos, donkeys, horses, camels and dogs.

Approval Year

PubMed

Title	Date	PubMed
Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.	1988 Jun	3137861
Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.	1992 Sep	1416885
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.	1995 Nov 24	7490723
The in vitro effects of isometamidium chloride (Samorin) on the piscine hemoflagellate Cryptobia salmositica (Kinetoplastida, Bodonina).	2001 Feb	11227891
A competitive enzyme-linked immunosorbent assay for diminazene.	2002 Nov	12429424
Cryptobia (Trypanoplasma) salmositica and salmonid cryptobiosis.	2003 Nov-Dec	14710756
Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis.	2004 Sep	15580765
Trypanocidal failure suggested by PCR results in cattle field samples.	2004 Sep	15301970
Point mutations in mitochondrial topoisomerase enzymes of Trypanosoma congolense are not involved in isometamidium resistance.	2007 Jan	17123643
Absence of correlation between karyotype profiles of Trypanosoma congolense and resistance to isometamidium chloride.	2007 Jul 20	17537578
Occurrence of multiple drug resistance in Trypanosoma brucei rhodesiense isolated from sleeping sickness patients.	2007 Mar	17708149
The history of African trypanosomiasis.	2008 Feb 12	18275594
Prevalence of bovine trypanosomosis and trypanocidal drug sensitivity studies on Trypanosoma congolense in Wolyta and Dawero zones of southern Ethiopia.	2008 Mar 25	18207329
Molecular tools for the rapid detection of drug resistance in animal trypanosomes.	2008 May	18420457
Assessment of the occurrence of trypanocidal drug resistance in trypanosomes of naturally infected cattle in the Adamaoua region of Cameroon using the standard mouse test and molecular tools.	2008 May	18355771

Sample Use Guides

In Vivo Use Guide

0.5 or 1.0 mg/kg bw.

Route of Administration: Intramuscular

Name

Type

Language

ISOMETAMIDIUM CHLORIDE

Official Name

English

isometamidium chloride [INN]

Common Name

English

A-4180

Code

English

8-(3-(M-AMIDINOPHENYL)-2-TRIAZENO)-3-AMINO-5-ETHYL-6-PHENYLPHENANTHRIDINIUM CHLORIDE

Systematic Name

English

ISOMETAMIDIUM CHLORIDE [MART.]

Common Name

English

ISOMETAMIDIUM CHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250