DETOMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2
Molecular Weight	186.253
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC(CC2=CNC=N2)=C1C

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N

InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

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Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 614 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8429	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.	2002 Dec	12492291
In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.	2002 Dec	12492290
The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate.	2002 Jul	12358052
Standing sedation and pain management for ophthalmic patients.	2004 Aug	15271436
Overdose during chemical restraint in a black rhinoceros (Diceros bicornis).	2005 Jan	15663740
Muscle metabolic changes associated with long-term inhalation anaesthesia in the horse analysed by muscle biopsy and microdialysis techniques.	2005 Mar	15737180
Human exposures to immobilising agents: results of an online survey.	2010 Aug 28	20802186
Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists.	2010 Jul-Aug	20492482
Immobilization and intravenous anesthesia in a Sumatran rhinoceros (Dicerorhinus sumatrensis).	2010 Mar	20722263
Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.	2010 Oct	20966270
Accidental poisoning with detomidine and butorphanol.	2010 Sep	20573843

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Name

Type

Language

DETOMIDINE

Official Name

English

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)

Common Name

English

detomidine [INN]

Common Name

English

DETOMIDINE [MI]

Common Name

English

4-(2,3-DIMETHYLBENZYL)IMIDAZOLE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QN05CM90