Gemcadiol is a lipid-regulating compound that was first described in 1977 in a study with hyperlipoproteinemia patients. It was concluded to be an effective antilipemic agent that is very well tolerated. Another study, conducted in 1986, showed that the compound was non-toxic in rodents, and decreased blood cholesterol. Also, liver weights were increased. Monkeys given 25 to 300 mg/kg gemcadiol for 13 weeks had slightly decreased serum cholesterol and slightly increased serum creatine phosphokinase. No effects on fetus/embryo in pregnant animals administered gemcadiol was observed in this study. No newer publications exist for this compound.