RIPISARTAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H22N8O
Molecular Weight	426.4738
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC1=C(CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=NN4)C5=NC(=O)NN5C(C)=N1

InChI

InChIKey=OLJAPHMBAMBVKL-UHFFFAOYSA-N

InChI=1S/C23H22N8O/c1-3-6-20-19(22-25-23(32)28-31(22)14(2)24-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-26-29-30-27-21/h4-5,7-12H,3,6,13H2,1-2H3,(H,28,32)(H,26,27,29,30)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8549620 | https://www.ncbi.nlm.nih.gov/pubmed/7628824 | https://www.medkoo.com/products/11220 | https://www.ncbi.nlm.nih.gov/pubmed/11150392

Ripisartan (UP-269-6) is a specific nonpeptide angiotensin II receptor antagonist. Oral administration of ripisartan in rats and dogs resulted in a dose-dependent and long-lasting inhibition of the angiotensin II-induced pressor response. It did not show agonistic properties in animals. In vitro, ripisartan was found to bind selectively to AT1 receptors. In humans, it showed high biliary excretion and reabsorption. Canine studies have suggested it might have cardioprotective properties after acute ischemia-reperfusion.

Approval Year

Name

Type

Language

RIPISARTAN

Official Name

English

UP-2696

Preferred Name

English

ripisartan [INN]

Common Name

English

5-METHYL-7-PROPYL-8-(P-(O-1H-TETRAZOL-5-YLPHENYL)BENZYL)-S-TRIAZOLO(1,5-C)PYRIMIDIN-2(3H)-ONE

Common Name

English

Ripisartan [WHO-DD]

Common Name

English

UP2696

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C66930