Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H19N |
Molecular Weight | 261.3609 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCC2=C(C1)C3=CC=CC=C3CC4=CC=CC=C24
InChI
InChIKey=GVPIXRLYKVFFMK-UHFFFAOYSA-N
InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3
DescriptionSources: http://www.drugbank.ca/drugs/DB09304http://link.springer.com/referenceworkentry/10.1007%2F978-3-540-68706-1_1842 | http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=36605Curator's Comment: Description was created based on several sources, including
https://www.drugbank.ca/drugs/DB09304
Sources: http://www.drugbank.ca/drugs/DB09304http://link.springer.com/referenceworkentry/10.1007%2F978-3-540-68706-1_1842 | http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=36605
Curator's Comment: Description was created based on several sources, including
https://www.drugbank.ca/drugs/DB09304
Setiptiline Maleate is a tetracyclic antidepressant that has been used in the treatment of depression. It has antihistamine and hypnotic–sedative effects, but almost no anticholinergic effects. It is a weak inhibitor of norepinephrine reuptake in vitro and strongly stimulates the release of central norepinephrine by blocking presynaptic α2-adrenoceptors similar to mianserin. It also acts as a 5-HT2A, 5-HT2C, and 5-HT3 receptor antagonist. Unlike most conventional antidepressants, it has no efficacy as a serotonin reuptake inhibitor. It can induce drowsiness and thirst, but it displays low toxicity. Setiptiline Maleate was launched in 1989 for the treatment of depression in Japan.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: GO:0007210 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3774630 |
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Target ID: CHEMBL2095158 Sources: http://www.ncbi.nlm.nih.gov/pubmed/2881854 |
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Target ID: CHEMBL2094251 Sources: http://www.genome.jp/dbget-bin/www_bget?D02034 |
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Target ID: CHEMBL2095200 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3774630 |
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Target ID: CHEMBL2095158 |
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Target ID: CHEMBL2094251 |
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Target ID: CHEMBL224 |
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Target ID: CHEMBL225 |
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Target ID: CHEMBL2094132 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Tecipul Approved UseAntidepressant Launch Date1997 |
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Sources: http://www.drugbank.ca/drugs/DB09304 |
Primary | Tecipul Approved UseFor the treatment of depression. Launch Date1997 |
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Primary | Setiptiline maleate Approved UseSetiptiline maleate is used to treat depression or depressive state Launch Date1988 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7905225
3-8 mg/day oral
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/7787763
100uM setiptiline inhibited about 60% of NMDA current in Xenopus oocytes injected with rat brain mRNA.
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C265
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DB09304
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CHEMBL2104895
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C050605
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m11743
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Setiptiline
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SUB10503MIG
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C75178
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DTXSID50205886
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7L38105Z6E
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)