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Details

Stereochemistry ACHIRAL
Molecular Formula C13H16N4O2
Molecular Weight 260.2917
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIAVERIDINE

SMILES

COC1=CC=C(CC2=C(N)N=C(N)N=C2)C=C1OC

InChI

InChIKey=LDBTVAXGKYIFHO-UHFFFAOYSA-N
InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)

HIDE SMILES / InChI

Description

Diaveridine is an antiprotozoal agent. It inhibits dihydrofolate reductase activity. Diaveridine is genotoxic to mammalian cells in vitro and in vivo. In veterinary it is used for the treatment of coccidiosis. It was reported that EGIS-5645 (considered to be diaveridine) exerts anti-inflammatory properties.

Originator

Burroughs Wellcome Fund
41
Curator's Comment: reference retrieved from www.drugfuture.com/chemdata/diaveridine.html

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
VERICOX

Approved Use

VERICOX is indicated for the treatment of coccidial intestinal and cecal infection in poultry
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.
1962 Nov
[Synthesis and antimycobacterial action of lipophilic substituted 2,4-diamino-5-benzylpyrimidines].
1988 Dec
Fine structural specificity differences of trimethoprim allergenic determinants.
1996 Oct
Patents

Patents

US2624732
1

Sample Use Guides

In Vivo Use Guide
VERICOX (1 g of water-soluble powder for oral use containing Sulphaquinoxaline Sodium 200 mg, Sulphadimidine sodium 250 mg, Diaveridine 50 mg, Vit. K3 20 mg) for the treatment of intestinal and cecal infection in poultry: broilers, turkeys: 1 gm per 2 liters of drinking water for 5-7 days.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Diaveridine is genotoxic to mammalian cells in vitro and in vivo.
Unknown
Name Type Language
DIAVERIDINE
INN   MART.   MI   USAN   USP-RS  
INN   USAN  
Official Name English
DIAVERIDINE [MI]
Common Name English
NSC-408735
Code English
DIAVERIDINE [USP-RS]
Common Name English
2,4-Diamino-5-veratrylpyrimidine
Systematic Name English
DIAVERIDINE [MART.]
Common Name English
BW-49210
Code English
DIAVERIDINE [USAN]
Common Name English
BW 49-210
Code English
2,4-PYRIMIDINEDIAMINE, 5-((3,4-DIMETHOXYPHENYL)METHYL)-
Systematic Name English
BW-49-210
Code English
diaveridine [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QP51AX18
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL19633
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
EPA CompTox
DTXSID2046200
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
CAS
5355-16-8
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
FDA UNII
7KVX81XA87
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
NSC
408735
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
NCI_THESAURUS
C167032
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
MERCK INDEX
m4264
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY Merck Index
PUBCHEM
21453
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
SMS_ID
100000082886
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
MESH
C033222
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
ECHA (EC/EINECS)
226-333-3
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
INN
1140
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
CHEBI
123115
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
RS_ITEM_NUM
1184118
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
EVMPD
SUB07068MIG
Created by admin on Fri Dec 15 17:27:12 UTC 2023 , Edited by admin on Fri Dec 15 17:27:12 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of DIAVERIDINE
NIH
NCATS
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