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Details

Stereochemistry ACHIRAL
Molecular Formula C13H16N4O2
Molecular Weight 260.2917
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIAVERIDINE

SMILES

COC1=CC=C(CC2=C(N)N=C(N)N=C2)C=C1OC

InChI

InChIKey=LDBTVAXGKYIFHO-UHFFFAOYSA-N
InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)

HIDE SMILES / InChI
Diaveridine is an antiprotozoal agent. It inhibits dihydrofolate reductase activity. Diaveridine is genotoxic to mammalian cells in vitro and in vivo. In veterinary it is used for the treatment of coccidiosis. It was reported that EGIS-5645 (considered to be diaveridine) exerts anti-inflammatory properties.

Originator

Curator's Comment: reference retrieved from www.drugfuture.com/chemdata/diaveridine.html

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
VERICOX

Approved Use

VERICOX is indicated for the treatment of coccidial intestinal and cecal infection in poultry
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
5-BENZYL-2,4-DIAMINOPYRIMIDINES AS ANTIBACTERIAL AGENTS. I. SYNTHESIS AND ANTIBACTERIAL ACTIVITY IN VITRO.
1962 Nov
Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs.
1992 Sep
Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
1996 Dec
In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii.
1998 Oct
Patents

Patents

Sample Use Guides

VERICOX (1 g of water-soluble powder for oral use containing Sulphaquinoxaline Sodium 200 mg, Sulphadimidine sodium 250 mg, Diaveridine 50 mg, Vit. K3 20 mg) for the treatment of intestinal and cecal infection in poultry: broilers, turkeys: 1 gm per 2 liters of drinking water for 5-7 days.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Diaveridine is genotoxic to mammalian cells in vitro and in vivo.
Unknown
Name Type Language
DIAVERIDINE
INN   MART.   MI   USAN   USP-RS  
INN   USAN  
Official Name English
DIAVERIDINE [MI]
Common Name English
NSC-408735
Code English
DIAVERIDINE [USP-RS]
Common Name English
2,4-Diamino-5-veratrylpyrimidine
Systematic Name English
DIAVERIDINE [MART.]
Common Name English
BW-49210
Code English
DIAVERIDINE [USAN]
Common Name English
BW 49-210
Code English
2,4-PYRIMIDINEDIAMINE, 5-((3,4-DIMETHOXYPHENYL)METHYL)-
Systematic Name English
BW-49-210
Code English
diaveridine [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QP51AX18
Created by admin on Fri Dec 15 17:27:12 GMT 2023 , Edited by admin on Fri Dec 15 17:27:12 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL19633
Created by admin on Fri Dec 15 17:27:12 GMT 2023 , Edited by admin on Fri Dec 15 17:27:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID2046200
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PRIMARY
CAS
5355-16-8
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PRIMARY
FDA UNII
7KVX81XA87
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PRIMARY
NSC
408735
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PRIMARY
NCI_THESAURUS
C167032
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PRIMARY
MERCK INDEX
m4264
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PRIMARY Merck Index
PUBCHEM
21453
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PRIMARY
SMS_ID
100000082886
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PRIMARY
MESH
C033222
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PRIMARY
ECHA (EC/EINECS)
226-333-3
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PRIMARY
INN
1140
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PRIMARY
CHEBI
123115
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PRIMARY
RS_ITEM_NUM
1184118
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PRIMARY
EVMPD
SUB07068MIG
Created by admin on Fri Dec 15 17:27:12 GMT 2023 , Edited by admin on Fri Dec 15 17:27:12 GMT 2023
PRIMARY