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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H42N4O8S2
Molecular Weight 554.721
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PANTETHINE

SMILES

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

InChIKey=DJWYOLJPSHDSAL-ROUUACIJSA-N
InChI=1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1

HIDE SMILES / InChI

Description

Pantethine, dimeric form of pantothenic acid, is a biologically active form of the B5 vitamin and an intermediate in the production of Coenzyme A. It is available as a dietary supplement, and is used support the healthy blood-cholesterol profile. Pantethine has shown an ability to favorably impact a variety of risk factors in people with hypercholesterolemia, arteriosclerosis and diabetes. It is thought that pantethine, in conjunction with the intermediary cysteamine, inhibits acetyl-coenzyme (CoA) carboxylase and 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, thereby affecting TG synthesis and lipoprotein metabolism. Pantethine increases CoA levels within the cells, which favorably modifies lipoprotein metabolism. The full mechanism of action of pantethine in lowering cholesterol levels is not fully understood. Since homocysteine is believed to contribute to the onset and progression of atherosclerosis and is involved in the biosynthesis of CoA, it is possible that pantethine impacts homocysteine.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Pantesin® Pantethine

PubMed

Sample Use Guides

In Vivo Use Guide
As a dietary supplement , take 1 tablet (247 mg pantethine) with food daily, or as directed by a healthcare professional.
Route of Administration: Oral
In Vitro Use Guide
The ability of pantetheine/pantethine to modulate the activity of HMG-CoA reductase was determined in vitro with rat liver microsomes. The decay of the activity was obtained with pantethine in the 10(-5)-10(-4) M range, whereas stimulation by pantetheine occurred at 10(-3)-10(-2) M, as previously reported for GSSG and GSH, respectively. Inhibition of HMG-CoA by pantethine in isolated liver cells was also investigated by measuring the enzyme activity in microsomes isolated from hepatocytes incubated without or with 1 mM pantethine.