ISOFEZOLAC

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H18N2O2
Molecular Weight	354.4012
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ISOFEZOLAC

Structure Search

SMILES

OC(=O)CC1=C(C(=NN1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

InChI

InChIKey=LZRDDINFIHUVCX-UHFFFAOYSA-N

InChI=1S/C23H18N2O2/c26-21(27)16-20-22(17-10-4-1-5-11-17)23(18-12-6-2-7-13-18)24-25(20)19-14-8-3-9-15-19/h1-15H,16H2,(H,26,27)

HIDE SMILES / InChI

Description
Sources: http://www.druglead.com/cds/Isofezolac.html | https://books.google.ru/books?id=j-3Cd_SWIksC&pg=PA319&lpg=PA319&dq=Isofezolac&source#v=onepage&q=Isofezolac&f=false

ISOFEZOLAC is a non-steroid anti-inflammatory drug, prostaglandin synthetase inhibitor. It is indicated for use in various forms of rheumatoid arthritis and osteoarthritis.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Study of two new non-steroid anti-inflammatory drugs having a pyrazole structure (LM 22070 and LM 22102).	1979 Apr	112931
The effect of antacid and aspirin on the bioavailability of isofezolac in man.	1984 Sep	6500763
Effect of probenecid on isofezolac kinetics.	1985	4029250

Name

Type

Language

ISOFEZOLAC

Official Name

English

isofezolac [INN]

Common Name

English

1,3,4-TRIPHENYLPYRAZOLE-5-ACETIC ACID

Systematic Name

English

Isofezolac [WHO-DD]

Common Name

English

ISOFEZOLAC [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257

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Code System Code Type Description

SMS_ID

100000082829

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FDA UNII

7K6U6T1360

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MERCK INDEX

m250

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Merck Index

INN

4438

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EVMPD

SUB08317MIG

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NCI_THESAURUS

C65977

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ChEMBL

CHEMBL2104795

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CAS

50270-33-2

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DRUG CENTRAL

1492

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EPA CompTox

DTXSID40198273

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PUBCHEM

68677

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MESH

C020696

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ECHA (EC/EINECS)

256-512-1

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ACTIVE MOIETY


					7K6U6T1360