Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H14N2S2 |
Molecular Weight | 238.372 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC(=S)C1(CCCS1)C2=NC=CC=C2
InChI
InChIKey=ITNLONMDUMHEOK-UHFFFAOYSA-N
InChI=1S/C11H14N2S2/c1-12-10(14)11(6-4-8-15-11)9-5-2-3-7-13-9/h2-3,5,7H,4,6,8H2,1H3,(H,12,14)
Picartamide had potent antisecretory and antiulcerogenic effects which were, at least, 10 times more pronounced than those of cimetidine. The mechanism of action of picartamide has not yet been determined but it seems that an anticholinergic or an H2 receptor antagonist effect should be excluded. The results show that picartamide is also active on the pure vagus-stimulated gastric acid secretion. The lack of effect upon gastric pepsin and plasma PP suggests that picartamide is not likely to act on the basolateral cholinergic receptor and that it affects further cellular steps involved in hydrogen ion secretion.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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[Antisecretory and antiulcer activities of N-methyl-2-(2-pyridyl)-2,3,4,5,-tetrahydro-2-thiophene-carbothioamide (R.P. .40, 749) (author's transl)]. | 1982 Mar 22 |
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Inhibition of pentagastrin-stimulated gastric secretion by pyridyl-2-tetrahydrothiophene derivative (RP 40749). | 1982 May 22 |
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[Inhibition by a 2-pyridyltetrahydrothiophene derivative (40749 RP) of gastric secretion stimulated by pentagastrin. Results in 30 duodenal ulcer patients]. | 1984 Feb |
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Increased effect of multiple doses of 40 749 RP a new long acting gastric antisecretory agent. | 1986 |
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Acute and chronic 24-hour gastric pH and pharmacokinetic studies with a long acting antisecretory drug (40749 RP) in peptic ulcer. | 1986 May |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3123255
A single dose of 2 mg/kg
Route of Administration:
Oral
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NCI_THESAURUS |
C29723
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C66380
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ACTIVE MOIETY