DIXYRAZINE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C24H33N3O2S
Molecular Weight	427.603
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(CN1CCN(CCOCCO)CC1)CN2C3=CC=CC=C3SC4=C2C=CC=C4

InChI

InChIKey=MSYUMPGNGDNTIQ-UHFFFAOYSA-N

InChI=1S/C24H33N3O2S/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27/h2-9,20,28H,10-19H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.drugfuture.com/mt/difebarbamate.pdf | https://www.ncbi.nlm.nih.gov/pubmed/3348073

Dixyrazine is a typical antipsychotic of the phenothiazine group. Under a trademark Esucos, the drug was used in European countries as an antipsychotic, antiemetic and sedative with oral doses ranging from 20 to 75 mg daily. Dixyrazine has also been given by injection.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Age estimation in 25-45 yrs. old females by physical and radiological methods.	2010-07	21731347
Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly?	2009-06-04	19497093
Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.	2009-05-16	19445700
Maternal use of antipsychotics in early pregnancy and delivery outcome.	2008-06	18480684
Preoperative sub-Tenon's capsule injection of ropivacaine in conjunction with general anesthesia in retinal detachment surgery.	2007-11	17445898
A two-year prospective study comparing lidocaine 2% jelly versus peribulbar anaesthesia for 25G and 23G sutureless vitrectomy.	2007-09	17342504
Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease.	2007-04-14	17505560
Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.	2004-11	15504190
Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting.	2004-07	15196110
Wound infiltration with ropivacaine and fentanyl: effects on postoperative pain and PONV after breast surgery.	2003-03	12719050
Topical anesthesia for cataract surgery: a population-based perspective.	2001-03	11255059

Sample Use Guides

In Vivo Use Guide

The oral dose of dixyrazine ranges from 20 to 75 mg daily. Dixyrazine has also been given by intramuscular injection at 0.5 mg/kg

Route of Administration: Other

Name

Type

Language

DIXYRAZINE

Common Name

English

ESUCOS

Preferred Name

English

ETHANOL, 2-(2-(4-(2-METHYL-3-PHENOTHIAZIN-10-YLPROPYL)-1-PIPERAZINYL)ETHOXY)-

Systematic Name

English

DIXYRAZINE [MART.]

Common Name

English

2-(2-(4-(2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)PIPERAZIN-1-YL)ETHOXY)ETHANOL

Systematic Name

English

UCB-3412

Code

English

DIXYRAZINE [MI]

Common Name

English

DYXIRAZINE

Common Name

English

ETHANOL, 2-(2-(4-(2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHOXY)-

Systematic Name

English

J21.394B

Code

English

Dixyrazine [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N05AB01