Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H13N3O4 |
| Molecular Weight | 311.2921 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(=CC=C1N2C(C)=NC3=C(C=CC=C3)C2=O)[N+]([O-])=O
InChI
InChIKey=RZHHDMJWDYJXAW-UHFFFAOYSA-N
InChI=1S/C16H13N3O4/c1-10-17-13-6-4-3-5-12(13)16(20)18(10)14-8-7-11(19(21)22)9-15(14)23-2/h3-9H,1-2H3
Approval Year
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Preferred Name | English | ||
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WIKIPEDIA |
Designer-drugs-Nitromethaqualone
Created by
admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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DTXSID80187601
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admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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340-52-3
Created by
admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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NITROMETHAQUALONE
Created by
admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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PRIMARY | Nitromethaqualone is an analogue of methaqualone that has similar sedative and hypnotic properties. It is significantly more potent (10x) compared to the parent compound the typical dose is approximately 25 mg. However, the aromatic nitro group is metabolised to the corresponding aniline, which proved to be a mutagen. As a consequence, nitromethaqualone was not developed further due to toxicity concerns. | ||
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7G855468ZM
Created by
admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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63339
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admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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NITROMETHAQUALONE
Created by
admin on Mon Mar 31 23:15:20 GMT 2025 , Edited by admin on Mon Mar 31 23:15:20 GMT 2025
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PRIMARY | With respect to nitromethaqualone: This compound is metabolized to 2-methoxy-4-nitroaniline, 2-methyl-3-(2'-methoxy-4'-aminophenyl)-4(3H)-quinazolinone and 2-methyl-3-(2'-methoxy-4'-acetylaminophenyl)-4(3H)-quinazolinone (see: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 1979, 41(4), p.275 later confirmed in: J Pharm Sci 1982, 71(10), p.1152). Of these three metabolites is the first one reportedly mutagenic (see: Annales des Falsifications de l'Expertise Chimique et Toxicologique 1987, 80(854), p.25), and the last one is produced from nitromethaqualone via the likewise mutagenic N-nitroso and N-hydroxy-intermediates. |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
