Lepodisiran Sodium

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Name

Type

Language

Lepodisiran Sodium

Official Name

English

LY-3819469 SODIUM

Preferred Name

English

RNA, ([4?-de(hydroxymethyl)-4?-[(hydroxymethoxyphosphinyl)methoxy]]Um-sp-(2?-deoxy-2?-fluoro)A-sp-(2?-deoxy-2?-fluoro)G-sp-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)U-Gm-(2?-deoxy-2?-fluoro)A-Cm-Cm-(2?-deoxy-2?-fluoro)A-Am-Gm-Cm-(2?-deoxy-2?-fluoro)U-Um-

Common Name

English

LY3819469 SODIUM

Code

English

LEPODISIRAN SODIUM [USAN]

Common Name

English

duplex of all-P-ambo-4?-de(hydroxymethyl)-4?-[(hydroxymethylphosphinoyl)methoxy]-2?-O-methylthiouridylyl-2?-deoxy-2?-fluorothioadenylyl-(3'?5')-2?-deoxy-2?-fluorothioguanylyl-(3'?5')-2?-deoxy-2?-fluoroadenylyl-(3'?5')-2?-deoxy-2?-fluorouridylyl-(3'?5')-2

Common Name

English

Code System Code Type Description

SMS_ID

300000046268

Created by admin on Wed Apr 02 11:33:20 GMT 2025 , Edited by admin on Wed Apr 02 11:33:20 GMT 2025

PRIMARY

CAS

2766131-24-0

Created by admin on Wed Apr 02 11:33:20 GMT 2025 , Edited by admin on Wed Apr 02 11:33:20 GMT 2025

PRIMARY

NCI_THESAURUS

C203138

Created by admin on Wed Apr 02 11:33:20 GMT 2025 , Edited by admin on Wed Apr 02 11:33:20 GMT 2025

PRIMARY

USAN

LM-87

Created by admin on Wed Apr 02 11:33:20 GMT 2025 , Edited by admin on Wed Apr 02 11:33:20 GMT 2025

PRIMARY

FDA UNII

7DR6F86F5U

Created by admin on Wed Apr 02 11:33:20 GMT 2025 , Edited by admin on Wed Apr 02 11:33:20 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_8-1_11;2_2-2_5;2_7;2_10;2_14	11 / 58
2'-O-Methyl-Ribose	1_1-1_7;1_12-1_36;2_1;2_6;2_8-2_9;2_11-2_13;2_15-2_22	47 / 58

Linkage	Site Range	Site Count
	1_3-1_36;2_5-2_20	50 / 56
Sodium Phosporothioate	1_2;2_2-2_4;2_21-2_22	6 / 56

SUBSTANCE RECORD


					7DR6F86F5U

Lepodisiran Sodium