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Details

Stereochemistry RACEMIC
Molecular Formula C29H30FN3O.ClH
Molecular Weight 492.027
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLEZELASTINE MONOHYDROCHLORIDE

SMILES

Cl.FC1=CC=C(CC2=NN(C3CCCN(CCC4=CC=CC=C4)CC3)C(=O)C5=C2C=CC=C5)C=C1

InChI

InChIKey=KBNISKYDAJMVNI-UHFFFAOYSA-N
InChI=1S/C29H30FN3O.ClH/c30-24-14-12-23(13-15-24)21-28-26-10-4-5-11-27(26)29(34)33(31-28)25-9-6-18-32(20-17-25)19-16-22-7-2-1-3-8-22;/h1-5,7-8,10-15,25H,6,9,16-21H2;1H

HIDE SMILES / InChI
FLEZELASTINE, a phthalazinone derivative, an anti-asthmatic/anti-allergic agent. It exhibits inhibition of histamine release and 5-lipoxygenase, calcium antagonistic properties and antagonism at the histamine H1 receptor. FLEZELASTINE is a racemate consisting of (+)- and (-)-enantiomers. Both enantiomers contribute to the pharmacodynamic efficacy of racemic flezelastine.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effects of flezelastine and its enantiomers on LPS-induced IL-1 beta generation in vitro and LPS-induced pyrexia in vivo.
1994 Mar
Azelastine and flezelastine as reversing agents of multidrug resistance: pharmacological and molecular studies.
1995 Jul 17
Name Type Language
FLEZELASTINE MONOHYDROCHLORIDE
Common Name English
1(2H)-PHTHALAZINONE, 4-((4-FLUOROPHENYL)METHYL)-2-(HEXAHYDRO-1-(2-PHENYLETHYL)-1H-AZEPIN-4-YL)-, HYDROCHLORIDE (1:1)
Systematic Name English
D-18024
Code English
FLEZELASTINE MONOHYDROCHLORIDE, (±)-
Common Name English
Code System Code Type Description
PUBCHEM
60431
Created by admin on Fri Dec 15 15:52:21 GMT 2023 , Edited by admin on Fri Dec 15 15:52:21 GMT 2023
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CAS
110406-33-2
Created by admin on Fri Dec 15 15:52:21 GMT 2023 , Edited by admin on Fri Dec 15 15:52:21 GMT 2023
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EPA CompTox
DTXSID30911635
Created by admin on Fri Dec 15 15:52:21 GMT 2023 , Edited by admin on Fri Dec 15 15:52:21 GMT 2023
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FDA UNII
7DAMTNUI2A
Created by admin on Fri Dec 15 15:52:21 GMT 2023 , Edited by admin on Fri Dec 15 15:52:21 GMT 2023
PRIMARY