Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C50H81N4O15P |
| Molecular Weight | 1009.1697 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 5 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC[C@@H]([C@H](O)[C@H](O)C(=O)NCC[C@H](C)C1=NC(\C=C\C[C@@H]2O[C@]3(C[C@@H](O)[C@@H]2C)O[C@H]([C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)\C=C(C)\C(C)=C\C=C\C(C)=C/C#N)OC)[C@H](OP(O)(O)=O)C3(C)C)=CO1)N(C)C
InChI
InChIKey=FKAWLXNLHHIHLA-YCBIHMBMSA-N
InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-35,37-46,55-59H,19,21,23,25-26,28H2,1-13H3,(H,52,60)(H2,61,62,63)/b16-14+,18-15+,29-20-,30-17+,32-24+/t31-,33+,34-,35-,37-,38-,39+,40-,41-,42+,43-,44-,45+,46-,50+/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens. | 2015-12 |
|
| RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα. | 2013-03 |
|
| Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. | 2012-02 |
|
| Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats. | 2012-02 |
|
| p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. | 2009-03-13 |
|
| Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. | 2008-09 |
|
| Protein phosphatase 1 activation and alternative splicing of Bcl-X and Mcl-1 by EGCG + ibuprofen. | 2008-07-01 |
|
| Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity. | 2007-05-18 |
|
| Calreticulin exposure dictates the immunogenicity of cancer cell death. | 2007-01 |
|
| Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. | 2006-10-19 |
|
| Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. | 2005-09 |
|
| Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. | 2004-12 |
|
| Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter. | 2004-04 |
|
| Possible involvement of optimally phosphorylated L-plastin in activation of superoxide-generating NADPH oxidase. | 2003-12 |
|
| Mechanism of cytosine arabinoside-mediated apoptosis: role of Rel A (p65) dephosphorylation. | 2003-07-10 |
|
| Reduction of beta-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated beta-catenin. | 2003-06 |
|
| Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130. | 2003-05-23 |
|
| Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. | 2001-10 |
|
| Functional and molecular characterization of the K-Cl cotransporter of Xenopus laevis oocytes. | 2001-08 |
|
| Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland. | 2001-07 |
|
| ATP induces dephosphorylation of myosin light chain in endothelial cells. | 2000-09 |
|
| Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. | 2000-03 |
|
| Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid. | 2000-02 |
|
| Regulation of renin secretion through reversible phosphorylation of myosin by myosin light chain kinase and protein phosphatase type 1. | 1998-06 |
|
| Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step. | 1994-12-01 |
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DB02860
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5311365
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DTXSID00883097
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Calyculin
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7D07U14TK3
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m2996
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101932-71-2
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SUBSTANCE RECORD
