Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H12ClNO2.ClH |
| Molecular Weight | 250.122 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC[C@@H](CC(O)=O)C1=CC=C(Cl)C=C1
InChI
InChIKey=WMNUVYYLMCMHLU-DDWIOCJRSA-N
InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m1./s1
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
12 mg 1 times / day multiple, oral (unknown) Highest studied dose Dose: 12 mg, 1 times / day Route: oral Route: multiple Dose: 12 mg, 1 times / day Sources: |
unhealthy, ADULT n = 11 Health Status: unhealthy Condition: Trigeminal neuralgia Age Group: ADULT Sex: unknown Food Status: UNKNOWN Population Size: 11 Sources: |
Other AEs: headedness, headache... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| headedness | 1 pt | 12 mg 1 times / day multiple, oral (unknown) Highest studied dose Dose: 12 mg, 1 times / day Route: oral Route: multiple Dose: 12 mg, 1 times / day Sources: |
unhealthy, ADULT n = 11 Health Status: unhealthy Condition: Trigeminal neuralgia Age Group: ADULT Sex: unknown Food Status: UNKNOWN Population Size: 11 Sources: |
| headache | mild, 1 pt | 12 mg 1 times / day multiple, oral (unknown) Highest studied dose Dose: 12 mg, 1 times / day Route: oral Route: multiple Dose: 12 mg, 1 times / day Sources: |
unhealthy, ADULT n = 11 Health Status: unhealthy Condition: Trigeminal neuralgia Age Group: ADULT Sex: unknown Food Status: UNKNOWN Population Size: 11 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The biological activity of d- and l-baclofen (Lioresal). | 1978 Nov 1 |
|
| Effects of intravenously administered enantiomers of baclofen on functionally identified units in lumbar dorsal horn of the spinal cat. | 1982 Nov |
|
| Stereoselectivity of spinal neurotransmission: effects of baclofen enantiomer on tail-flick reflex in rats. | 1984 |
|
| Potential involvement of a baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro. | 1988 Mar |
|
| Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution. | 1989 |
|
| Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. | 1991 Apr 24 |
|
| Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures. | 1992 Apr |
|
| NMDA receptor antagonists block cardiovascular responses to intrathecal administration of D-baclofen in the rat. | 1992 Jun 5 |
|
| Effects of L-baclofen and D-baclofen on the auditory system: a study of click-evoked potentials from the inferior colliculus in the rat. | 1995 May |
|
| Permeation and systemic absorption of R- and S-baclofen across the nasal mucosa. | 2011 Jul |
|
| Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice. | 2014 Oct 1 |
|
| Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption. | 2015 Feb |
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C29696
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C90889
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
PRIMARY | |||
|
DTXSID00213113
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
PRIMARY | |||
|
799SU69U5P
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
PRIMARY | |||
|
44599
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
PRIMARY | |||
|
63701-56-4
Created by
admin on Fri Dec 15 17:34:22 GMT 2023 , Edited by admin on Fri Dec 15 17:34:22 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
