Penoxsulam, a fluorinated benzenesulfonamid rice herbicide is sold under the brand name Granite. Penoxsulam is an acetolactate synthase inhibitor that kills plants through a mechanism not present in animals and has few to no adverse effects on most species. Besides, was found that Chlorella Vulgaris dietary supplementation could protect the commercially valuable freshwater fish Oreochromis niloticus against penoxsulam toxicity and may be a potential feed supplement for Nile tilapia in aquaculture.