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Details

Stereochemistry ABSOLUTE
Molecular Formula C15H15N7O4S3
Molecular Weight 453.519
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of CEFIVITRIL

SMILES

[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@H]2NC(=O)CS\C=C/C#N)C(O)=O

InChI

InChIKey=JXHWKLWIYBATLL-GMIKGCRTSA-N
InChI=1S/C15H15N7O4S3/c1-21-15(18-19-20-21)29-6-8-5-28-13-10(12(24)22(13)11(8)14(25)26)17-9(23)7-27-4-2-3-16/h2,4,10,13H,5-7H2,1H3,(H,17,23)(H,25,26)/b4-2-/t10-,13-/m1/s1

HIDE SMILES / InChI
Cefivitril is a semi-synthetic cephalosporin with broad antibacterial activity against penicillin-resistant strains of S. aureus. Compared with the other cephalosporin, Cefivitril showed a better in vitro activity on gram pos. and gram neg. bacteria. Sensitivity tests were performed with 1007 bacterial strains to evaluate the in vitro activity of Cefivitril compared with that of cefuroxime and cephapirin. Compared with cefuroxiime and cephaprin, Cefivitril activity was significantly higher on Pasteurella and Salmonella, whereas no significant differences were detected for Streptococcus, Proteus, and Pseudomonas.

Approval Year

PubMed

PubMed

TitleDatePubMed
Cephalosporins. II. Synthesis and structure-activity relationships of new 7-vinylenethioacetamido and thioacrylamido cephalosporins.
1981 Apr
Patents

Patents

Name Type Language
CEFIVITRIL
INN  
INN  
Official Name English
cefivitril [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C357
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID501024387
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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FDA UNII
776E09GMHQ
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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ChEMBL
CHEMBL2104442
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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EVMPD
SUB07394MIG
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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NCI_THESAURUS
C76167
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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PUBCHEM
6443795
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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INN
5667
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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CAS
66474-36-0
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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SMS_ID
100000081820
Created by admin on Fri Dec 15 16:28:56 GMT 2023 , Edited by admin on Fri Dec 15 16:28:56 GMT 2023
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