ADIPIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H10O4
Molecular Weight	146.1412
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CCCCC(O)=O

InChI

InChIKey=WNLRTRBMVRJNCN-UHFFFAOYSA-N

InChI=1S/C6H10O4/c7-5(8)3-1-2-4-6(9)10/h1-4H2,(H,7,8)(H,9,10)

HIDE SMILES / InChI

Description
Sources: https://www.thechemco.com/chemical/adipic-acid/

Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain a pH-independent release for both weakly basic and weakly acidic drugs. It has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of hydrophilic drugs. The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when adipic acid was used as a pore-forming agent without affecting release in the acidic media. Adipic acid is used to make bisobrin an antifibrinolytic.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Organic acids in aqueous humour and plasma: post mortem study in infants and diagnosis of enzymopathies.	1991	1779612
Structural analyses and magnetic properties of 3D coordination polymeric networks of nickel(II) maleate and manganese(II) adipate with the flexible 1,2-bis(4-pyridyl)ethane ligand.	2003 Apr 21	12691577
Release profiles of theophylline from microspheres consisting of dextran derivatives and cellulose acetate butyrate: effect of polyion complex formation.	2003 Aug	12906337
Bioavailability of theophylline and thiamine disulfide incorporated into mucoadhesive microspheres consisting of dextran derivatives and cellulose acetate butyrate.	2003 Dec	14646183
Influence of the adipate and dissolved oxygen concentrations on the beta-lactam production during continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus.	2003 Jan	12749843
Alicycliphilus denitrificans gen. nov., sp. nov., a cyclohexanol-degrading, nitrate-reducing beta-proteobacterium.	2003 Jan	12661531
A new approach in gastroretentive drug delivery system using cholestyramine.	2003 Jul-Sep	12944135
Di(2-ethylhexyl) adipate (DEHA) induced developmental toxicity but not antiandrogenic effects in pre- and postnatally exposed Wistar rats.	2003 Mar-Apr	12642148
Determination of endocrine-disrupting compounds in water samples by on-line solid-phase extraction-programmed-temperature vaporisation-gas chromatography-mass spectrometry.	2003 May 23	12862370
Herbaspirillum lusitanum sp. nov., a novel nitrogen-fixing bacterium associated with root nodules of Phaseolus vulgaris.	2003 Nov	14657133
Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1.	2004 Aug	15284288
A new system in organooxotin cluster chemistry incorporating inorganic and organic spacers between two ladders each containing five tin atoms.	2004 Aug 6	15281160
Synthesis and characterization of new Mg(2)Al-paratungstate layered double hydroxides.	2004 Jan 12	14704090
Crystal structure and spectroscopic study of novel two- and three-dimensional photoluminescent Eu(III)-adipate compounds.	2004 Jan 12	14704074
catena-Poly[[mu-hexanedioato-1kappaO1:2kappaO6-bis[aqua(5-carboxypentanoato-kappaO)copper(II)]]-di-mu-4,4'-bipyridine-1kappaN:1'kappaN';2kappaN:2'kappaN'].	2005 Dec	16330830
Conversion of food waste into hydrogen by thermophilic acidogenesis.	2005 Feb	15727153
Cellulose acetate butyrate microcapsules containing dextran ion-exchange resins as self-propelled drug release system.	2005 Jul	15683658
Templated metal-organic frameworks: synthesis, structures, thermal properties and solid-state transformation of two novel calcium-adipate frameworks.	2005 Jun 21	15957051
Alkane oxidation by osmium tetroxide.	2005 Mar 9	15740101
Preparation and in vitro evaluation of propylthiouracil microspheres made of Eudragit RL 100 and cellulose acetate butyrate polymers using the emulsion-solvent evaporation method.	2005 May	16019914
Functional characterization of high-affinity Na(+)/dicarboxylate cotransporter found in Xenopus laevis kidney and heart.	2005 Nov	15944208
Increased biological hydrogen production with reduced organic loading.	2005 Oct	16129472
Tweezing-adsorptive bubble separation. Analytical method for the selective and high enrichment of metalloenzymes.	2005 Oct 1	16194067
catena-Poly[[diaquabis(5-carboxypentanoato-kappaO)cobalt(II)]-mu-1,2-di-4-pyridylethane-kappa2N:N'].	2005 Sep	16143764
Production of 1,3-Propanediol by Clostridium butyricum VPI 3266 in continuous cultures with high yield and productivity.	2005 Sep	16044292
Uniaxial drawing of poly[(R)-3-hydroxybutyrate]/cellulose acetate butyrate blends and their orientation behavior.	2005 Sep 16	16136569
Amended final report of the safety assessment of dibutyl adipate as used in cosmetics.	2006	16835133
Matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectra of poly(butylene adipate).	2006	16645991
Ala-504 is a determinant of substrate binding affinity in the mouse Na(+)/dicarboxylate cotransporter.	2006 Jun	16787639
Modelling calcium carbonate biomineralisation processes.	2006 May	16650477
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Molecular model for host–guest interaction of tetraamino-tert-butylthiacalix[4]arene and tetraamino-tert-butylcalix[4]arene receptors with carboxylate and dicarboxylate guests: an ONIOM study.	2007	16738872
Cellulose acetate butyrate-pH/thermosensitive polymer microcapsules containing aminated poly(vinyl alcohol) microspheres for oral administration of DNA.	2007 Apr	17085025
Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria.	2007 Aug	17722982
Adipic and malonic acid aqueous solutions: surface tensions and saturation vapor pressures.	2007 Dec 20	18044850
Fluxome analysis using GC-MS.	2007 Feb 7	17286851
The relationship between instability of H2 production and compositions of bacterial communities within a dark fermentation fluidized-bed bioreactor.	2007 Jul 1	17163514
Effect of the dispersion of Eudragit S100 powder on the properties of cellulose acetate butyrate microspheres containing theophylline made by the emulsion-solvent evaporation method.	2007 May	17454437
Exploring lanthanide luminescence in metal-organic frameworks: synthesis, structure, and guest-sensitized luminescence of a mixed europium/terbium-adipate framework and a terbium-adipate framework.	2007 May 14	17439205
[(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.	2007 Sep	18404448
Diverse entangled metal-organic framework materials incorporating kinked organodiimine and flexible aliphatic dicarboxylate ligands: synthesis, structure, physical properties, and reversible structural reorganization.	2007 Sep 3	17691722
Preparation and characterization of hydroxyapatite/poly(ethylene adipate) hybrid composites.	2008	18544239
Organic acid concentrations in amniotic fluid found in normal and Down syndrome pregnancies.	2008	18417986
Prenatal phenol and phthalate exposures and birth outcomes.	2008 Aug	18709157
Determination of insulin in innovative formulations by means of LC coupled to fluorescence detection.	2008 Dec 15	18952391
Compatibility study of trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (TNAD) with some energetic components and inert materials.	2008 Dec 30	18434010
Diclofenac sodium loaded-cellulose acetate butyrate: effect of processing variables on microparticles properties, drug release kinetics and ulcerogenic activity.	2008 Feb	18188730
Determination of phthalates and adipate in bottled water by headspace solid-phase microextraction and gas chromatography/mass spectrometry.	2008 Jan 18	18082753
Proteomic investigation of amino acid catabolism in the indigenous gut anaerobe Fusobacterium varium.	2008 Jul	18546150
Release profile comparison and stability of diltiazem-resin microcapsules in sustained release suspensions.	2008 Mar 20	18061381

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

ADIPIC ACID

Official Name

English

ADIPIC ACID [FCC]

Common Name

English

NSC-7622

Code

English

HEXANEDIOIC ACID

Systematic Name

English

1,4-Butanedicarboxylic acid

Systematic Name

English

ADIPIC ACID [FHFI]

Common Name

English

ADIPIC ACID [USP-RS]

Common Name

English

Adipic acid [WHO-DD]

Common Name

English

ADIPIC ACID [MART.]

Common Name

English

E-355

Code

English

ADIPINIC ACID

Common Name

English

FEMA NO. 2011

Code

English

ADIPIC ACID [HSDB]

Common Name

English

INS NO.355

Code

English

INS-355

Code

English

ADIPIDIC ACID

Common Name

English

ADIPIC-ACID

Systematic Name

English

ADIPIC ACID [INCI]

Common Name

English

ADIPIC ACID [II]

Common Name

English

ADIPIC ACID [MI]

Common Name

English

ADIPIC ACID [EP MONOGRAPH]

Common Name

English

Classification Tree Code System Code

CFR

21 CFR 184.1009