ENMD-1198

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25NO2
Molecular Weight	311.418
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C(CC[C@H]3[C@@H]4CC=C[C@@]4(C)CC[C@H]23)C=C1C(N)=O

InChI

InChIKey=YQJWOUQGXATDAE-ACNBBOPNSA-N

InChI=1S/C20H25NO2/c1-20-8-3-4-17(20)14-6-5-12-10-16(19(21)22)18(23-2)11-15(12)13(14)7-9-20/h3,8,10-11,13-14,17H,4-7,9H2,1-2H3,(H2,21,22)/t13-,14+,17-,20-/m0/s1

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties.	2010-05	20442304
Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol.	2009-11-01	19782564
ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.	2008-07-23	18651980
A comparison of two orally bioavailable anti-cancer agents, IRC-110160 and STX140.	2008-07-18	18630502
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.	2008-06	18566218

Patents

Name

Type

Language

ENMD-1198

Common Name

English

IRC-110160

Preferred Name

English

ESTRA-1(10),2,4,16-TETRAENE-3-CARBOXAMIDE, 2-METHOXY-

Systematic Name

English

2-METHOXYESTRA-1(10),2,4,16-TETRAENE-3-CARBOXAMIDE

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB05959