POMIFERIN

Possibly Marketed Outside US

First approved in 2022

CC(C)=CCC1=C2OC(C)(C)C=CC2=C3OC=C(C(=O)C3=C1O)C4=CC(O)=C(O)C=C4

InChIKey=GHCZYXUOYFOXIP-UHFFFAOYSA-N

InChI=1S/C25H24O6/c1-13(2)5-7-15-21(28)20-22(29)17(14-6-8-18(26)19(27)11-14)12-30-24(20)16-9-10-25(3,4)31-23(15)16/h5-6,8-12,26-28H,7H2,1-4H3

Targets

Primary Target	Pharmacology	Potency
histone deacetylase 1 Target ID: histone deacetylase Sources: https://www.ncbi.nlm.nih.gov/pubmed/17662606	Inhibitor 8297	1.0 µM [IC50]
Carbonic anhydrase 1 3 Target ID: P00915 Gene ID: 759.0 Gene Symbol: CA1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28338341	Inhibitor 8297	471.0 µM [Ki]
Carbonic anhydrase 2 5 Target ID: P00918 Gene ID: 760.0 Gene Symbol: CA2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28338341	Inhibitor 8297	235.7 µM [Ki]

PubMed

Title	Date	PubMed
Pomiferin.	2003 Mar	12711784
Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid.	2003 Oct 22	14558760
Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide.	2008 Sep 10	18597965
Examining the genomic influence of skin antioxidants in vitro.	2010	20706672
Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats.	2010 Jun	21217877
Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells.	2010 Mar 10	20036234

Patents

Name

Type

Language

POMIFERIN

Official Name

English

4H,8H-BENZO(1,2-B:3,4-B')DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTENYL)-

Systematic Name

English

POMIFERIN [INCI]

Common Name

English

3'-HYDROXYOSAJIN

Common Name

English

4H,8H-BENZO(1,2-B:3,4-B')DIPYRAN-4-ONE, 3-(3,4-DIHYDROXYPHENYL)-5-HYDROXY-8,8-DIMETHYL-6-(3-METHYL-2-BUTEN-1-YL)-

Systematic Name

English

NSC-5113

Code

English

Code System Code Type Description

FDA UNII

74YIS40APM