Details
Stereochemistry | ACHIRAL |
Molecular Formula | C27H34N4 |
Molecular Weight | 414.5857 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 2 |
SHOW SMILES / InChI
SMILES
CC[N+](C)(CC)CCC[N+]1=C(C2=CC=CC=C2)C3=C(C=CC(N)=C3)C4=C1C=C(N)C=C4
InChI
InChIKey=ZDWVWKDAWBGPDN-UHFFFAOYSA-O
InChI=1S/C27H33N4/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3/q+1/p+1
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL220 |
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Target ID: DNA Sources: https://www.ncbi.nlm.nih.gov/pubmed/15633997 |
PubMed
Title | Date | PubMed |
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Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of Leishmania infantum promastigotes. | 2001 |
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In vitro dedifferentiation of fetal porcine pancreatic tissue prior to transplantation as islet-like cell clusters. | 2001 |
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Verocytotoxin-induced apoptosis of human microvascular endothelial cells. | 2001 Apr |
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Cytotoxicity of anti-CD64-ricin a chain immunotoxin against human acute myeloid leukemia cells in vitro and in SCID mice. | 2001 Feb |
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Green-light transilluminator for the detection without photodamage of proteins and DNA labeled with different fluorescent dyes. | 2001 Feb |
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The decrease of PKCalpha is associated with hepatic apoptosis at early and late phases of polymicrobial sepsis. | 2001 Feb |
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Inhibition of apoptosis: a potential mechanism for syndromic craniosynostosis. | 2001 Feb |
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Puromycin aminonucleoside induces glomerular epithelial cell apoptosis. | 2001 Feb |
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Calcium homeostasis and cell death in Sol8 dystrophin-deficient cell line in culture. | 2001 Feb |
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Suramin prevents cerebellar granule cell-death induced by dequalinium. | 2001 Feb |
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Progressive disruption of the plasma membrane during renal proximal tubule cellular injury. | 2001 Feb 15 |
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Pharmacological interventions of cyanide-induced cytotoxicity and DNA damage in isolated rat thymocytes and their protective efficacy in vivo. | 2001 Feb 3 |
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Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 Jan |
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Effects of genotypically different strains of Helicobacter pylori on human microvascular endothelial cells in vitro. | 2001 Jan |
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Induction of final maturation by sperm penetration in canine oocytes. | 2001 Jan |
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Radiation sensitivity and apoptosis in human lymphoma cells. | 2001 Jan |
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Elevated caspase-3 activity in peripheral blood T cells coexists with increased degree of T-cell apoptosis and down-regulation of TCR zeta molecules in patients with gastric cancer. | 2001 Jan |
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NASA/American Cancer Society High-Resolution Flow Cytometry Project - II. Effect of pH and DAPI concentration on dual parametric analysis of DNA/DAPI fluorescence and electronic nuclear volume. | 2001 Jan 1 |
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Hydration changes for DNA intercalation reactions. | 2001 Jan 10 |
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Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes. | 2001 Jan 16 |
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High oxygen tension leads to acute cell death in organotypic hippocampal slice cultures. | 2001 Jan 31 |
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Fluorescent probes and flow cytometry to assess rat sperm integrity and mitochondrial function. | 2001 Jan-Feb |
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In vivo effects of apoptosis in asthma examined by a murine model. | 2001 Jan-Mar |
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Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes. | 2001 Mar |
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Chromatin status in human ejaculated spermatozoa from infertile patients and relationship to seminal parameters. | 2001 Mar |
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Signal transduction of flumazenil-induced preconditioning in myocytes. | 2001 Mar |
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Quantitative analysis of specific mRNA species in minute cell samples by RT-PCR and flow cytometry. | 2001 Mar 1 |
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Fas-L up-regulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression. | 2001 Mar 1 |
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Bi-directional effects of the elevation of intracellular calcium on the expression of inducible nitric oxide synthase in J774 macrophages exposed to low and to high concentrations of endotoxin. | 2001 Mar 1 |
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Flow cytometric assay for evaluation of the effects of cell density on cytotoxicity and induction of apoptosis. | 2001 Mar 1 |
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Cell cycle arrest of hematopoietic cell lines after treatment with ceramide is commonly associated with retinoblastoma activation. | 2001 Mar 1 |
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Synthetic phytoceramides induce apoptosis with higher potency than ceramides. | 2001 May |
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DTXSID20189583
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36015-30-2
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D011419
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4939
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Propidium
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74NX23J96Y
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DB02166
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SUBSTANCE RECORD