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Details

Stereochemistry ACHIRAL
Molecular Formula C6H12N2O12P4.5Na.Sm
Molecular Weight 695.9317
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

SMILES

[Na+].[Na+].[Na+].[Na+].[Na+].[153Sm+3].[O-]P([O-])(=O)CN(CCN(CP([O-])([O-])=O)CP([O-])([O-])=O)CP([O-])([O-])=O

InChI

InChIKey=SZZACTGRBZTAKY-NKNBZPHVSA-F
InChI=1S/C6H20N2O12P4.5Na.Sm/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20;;;;;;/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;;;/q;5*+1;+3/p-8/i;;;;;;1+3

HIDE SMILES / InChI
Samarium SM-153 lexidronam is a chelated complex of a radioisotope of the element samarium with ethylenediamine tetra(methylene phosphonic acid) (EDTMP). Samarium Sm-153 EDTMP has an affinity for bone and concentrates in areas of bone turnover in association with hydroxyapatite. In clinical studies employing planar imaging techniques, more Samarium (153Sm) lexidronam accumulates in osteoblastic lesions than in normal bone with a lesion-to-normal bone ratio of approximately 5. It is indicated for the relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan. It should not be given concurrently with chemotherapy or external beam radiation therapy unless the benefit outweighs the risks. The most common adverse events are: nausea and vomiting, hemoglobin decrease, myasthenia, paresthesia, thrombocytopenia and abdominal pain.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
QUADRAMET

Approved Use

QUADRAMET® is indicated for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan.

Launch Date

1997

Sample Use Guides

The recommended dose of QUADRAMET® is 1.0 mCi/kg, administered intravenously over a period of one minute through a secure in-dwelling catheter and followed with a saline flush.
Route of Administration: Intravenous
Name Type Language
SAMARIUM SM-153 LEXIDRONAM PENTASODIUM
ORANGE BOOK  
Common Name English
CYT-424
Code English
SAMARIUM SM 153 LEXIDRONAM PENTASODIUM SALT [MI]
Common Name English
SAMARIUM (153SM) LEXIDRONAM PENTASODIUM
EMA EPAR  
Common Name English
SAMARIUM (153SM) LEXIDRONAM SODIUM [JAN]
Common Name English
SAMARIUM (153SM) LEXIDRONAM PENTASODIUM [EMA EPAR]
Common Name English
SAMARIUM SM153 LEXIDRONAM PENTASODIUM
Common Name English
SAMARIUM SM-153 LEXIDRONAM PENTASODIUM [ORANGE BOOK]
Common Name English
Samarium (153 sm) lexidronam pentasodium [WHO-DD]
Common Name English
SM-153 EDTMP PENTASODIUM
Common Name English
SAMARIUM SM 153 LEXIDRONAM PENTASODIUM [USAN]
Common Name English
SAMARIUM SM 153 LEXIDRONAM PENTASODIUM
USAN  
USAN  
Official Name English
SAMARIUM (153SM) LEXIDRONAM SODIUM
Common Name English
SAMARIUM SM 153 LEXIDRONAM PENTASODIUM SALT
MI  
Common Name English
QUADRAMET
Brand Name English
Classification Tree Code System Code
NDF-RT N0000000205
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
NCI_THESAURUS C2124
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
EMA ASSESSMENT REPORTS QUADRAMET (AUTHORIZED: PAIN)
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
NDF-RT N0000175872
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
Code System Code Type Description
SMS_ID
100000089138
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
CAS
160369-78-8
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
SUPERSEDED
LACTMED
Samarium Sm 153 Lexidronam Pentasodium
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
MERCK INDEX
m9757
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C1220
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
RXCUI
317675
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY RxNorm
DRUG BANK
DBSALT002635
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
EVMPD
SUB15188MIG
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
USAN
GG-67
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
PUBCHEM
9810246
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
FDA UNII
7389YR3OOV
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
CAS
176669-18-4
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY
ChEMBL
CHEMBL2109931
Created by admin on Fri Dec 15 15:54:42 GMT 2023 , Edited by admin on Fri Dec 15 15:54:42 GMT 2023
PRIMARY