Details
Stereochemistry | EPIMERIC |
Molecular Formula | C23H33NO8 |
Molecular Weight | 451.51 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 6 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1([C@@H](C)O)C(=O)N2C(C(=O)OC(C)OC(=O)OC3CCCCC3)=C4[C@H](CCC[C@]4([H])[C@]12[H])OC
InChI
InChIKey=QFEICXCLIGZEJB-IRVPUMQPSA-N
InChI=1S/C23H33NO8/c1-12(25)17-19-15-10-7-11-16(29-3)18(15)20(24(19)21(17)26)22(27)30-13(2)31-23(28)32-14-8-5-4-6-9-14/h12-17,19,25H,4-11H2,1-3H3/t12-,13?,15+,16+,17-,19-/m1/s1
Sanfetrinem cilexetil (formerly known as GV 118819), a beta-lactam antibiotic, is the oral prodrug of sanfetrinem. Experiments on rodents have revealed that sanfetrinem cilexetil had strong antibacterial activity in vitro and good pharmacokinetic behavior in mice. This drug was suitable for the treatment of infections caused by a variety of bacteria and participated in a phase II clinical trial. However, this study was discontinued.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Automated assay for GV104326, a novel tribactam antibiotic, in human plasma by high-performance liquid chromatography and solid-phase extraction. | 1994 Feb 4 |
|
Sanfetrinem and sanfetrinem-cilexetil: disposition in rat and dog. | 1997 Jul |
|
In vivo antibacterial activities of sanfetrinem cilexetil, a new oral tricyclic antibiotic. | 1998 Jul |
|
Carboxylesterases, a key factor in evaluating potential genotoxicity of Trinem antibiotics. | 2000 Jan |
|
[Sanfetrinem, the member of trinems--in vitro activity against Klebsiella pneumoniae producing ESBL]. | 2006 |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8950528
The activity of sanfetrinem was determined using a broth microdilution MIC method versus a large number of clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis obtained in a recent 30-center United States surveillance study. The sanfetrinem MIC50 and MIC90 values for these three organism groups were 0.015 and 0.5 microgram/ml, 0.25, and 0.5 microgram/ml, and 0.015 and 0.03, respectively.
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C260
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
6918217
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
CHEMBL2107073
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
C152296
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
7322RJ9FZB
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
DTXSID80109991
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
HH-57
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY | |||
|
141646-08-4
Created by
admin on Fri Dec 15 15:55:36 GMT 2023 , Edited by admin on Fri Dec 15 15:55:36 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD