Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H24N2 |
| Molecular Weight | 280.4073 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C13
InChI
InChIKey=UKCVXGBHVGMFCN-UHFFFAOYSA-N
InChI=1S/C19H24N2/c1-20(2)12-7-13-21-15-18-10-4-3-8-16(18)14-17-9-5-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
Prazepine is a tricyclic antidepressant (TCA). Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location. Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests. Prazepine showed potent antihistaminic properties.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Comparison of pharmacological properties of propazepine and imipramine]. | 1961 May |
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| Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome. | 1999 Dec 15 |
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| Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. | 2000 Jul 28 |
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| Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex. | 2001 Apr 6 |
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| QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. | 2005 Mar |
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| [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
|
| Manifestation of psychiatric behaviors in a mouse model of griseofulvin-induced hepatic porphyria. | 2008 Dec |
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NCI_THESAURUS |
C265
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C66459
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1916
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CHEMBL2105257
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100000081400
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299322
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72O4809PU1
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172129
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DTXSID00223272
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73-07-4
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SUB10007MIG
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Propazepine
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ACTIVE MOIETY
