TOLNAPERSINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H26N2O
Molecular Weight	322.4439
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=CC=C1N2CCN(CC2)C3CCC4=C(C3)C=CC(O)=C4

InChI

InChIKey=ZYGBSDBJSDMKLV-UHFFFAOYSA-N

InChI=1S/C21H26N2O/c1-16-4-2-3-5-21(16)23-12-10-22(11-13-23)19-8-6-18-15-20(24)9-7-17(18)14-19/h2-5,7,9,15,19,24H,6,8,10-14H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3841005 | https://www.ncbi.nlm.nih.gov/pubmed/8070010 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1216, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Tolnapersine is an antihypertensive drug. It is a compound with mixed dopamine agonist and alpha-adrenoceptor antagonist activity. Tolnapersine at a dose of 50 mg resulted in a fall in mean blood pressure. Tolnapersine at the higher dose produced a significant tachycardia, which would be compatible with a compensatory response to vasodilation. Also, at the higher dose tolnapersine produces sedation. Many compounds have been reported as potential reversing agents of multidrug resistance. Tolnapersine yielded a good activity (ratio of > 10).

Approval Year

PubMed

Title	Date	PubMed
Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds.	1994	8070010
Studies on the pharmacological control of gastric emptying in man.	1985-10	3841005

Sample Use Guides

In Vivo Use Guide

50 and 100 mg

Route of Administration: Oral

Name

Type

Language

NSC-757872

Preferred Name

English

TOLNAPERSINE

Official Name

English

5,6,7,8-TETRAHYDRO-6-(4-O-TOLYL-1-PIPERAZINYL)-2-NAPHTHOL

Common Name

English

(±)-5,6,7,8-TETRAHYDRO-6-(4-O-TOLYL-1-PIPERAZINYL)-2-NAPHTHOL

Common Name

English

tolnapersine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270