TOLNAPERSINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H26N2O
Molecular Weight	322.4439
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C=CC=C1)N2CCN(CC2)C3CCC4=C(C3)C=CC(O)=C4

InChI

InChIKey=ZYGBSDBJSDMKLV-UHFFFAOYSA-N

InChI=1S/C21H26N2O/c1-16-4-2-3-5-21(16)23-12-10-22(11-13-23)19-8-6-18-15-20(24)9-7-17(18)14-19/h2-5,7,9,15,19,24H,6,8,10-14H2,1H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3841005 | https://www.ncbi.nlm.nih.gov/pubmed/8070010 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 1216, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Tolnapersine is an antihypertensive drug. It is a compound with mixed dopamine agonist and alpha-adrenoceptor antagonist activity. Tolnapersine at a dose of 50 mg resulted in a fall in mean blood pressure. Tolnapersine at the higher dose produced a significant tachycardia, which would be compatible with a compensatory response to vasodilation. Also, at the higher dose tolnapersine produces sedation. Many compounds have been reported as potential reversing agents of multidrug resistance. Tolnapersine yielded a good activity (ratio of > 10).

Approval Year

PubMed

Title	Date	PubMed
Studies on the pharmacological control of gastric emptying in man.	1985 Oct	3841005
Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds.	1994	8070010

Sample Use Guides

In Vivo Use Guide

50 and 100 mg

Route of Administration: Oral

Name

Type

Language

TOLNAPERSINE

Official Name

English

5,6,7,8-TETRAHYDRO-6-(4-O-TOLYL-1-PIPERAZINYL)-2-NAPHTHOL

Common Name

English

NSC-757872

Code

English

(±)-5,6,7,8-TETRAHYDRO-6-(4-O-TOLYL-1-PIPERAZINYL)-2-NAPHTHOL

Common Name

English

tolnapersine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270