U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Pramlintide is an analog of human amylin. Amylin is co-secreted with insulin from pancreatic beta cells and acts centrally to slow gastric emptying, suppress postprandial glucagon secretion, and decrease food intake. These actions complement those of insulin to regulate blood glucose concentrations. Amylin is relatively deficient in patients with type 2 diabetes, depending on the severity of beta-cell secretory failure, and is essentially absent in patients with type 1 diabetes. Through mechanisms similar to those of amylin, pramlintide improves overall glycemic control, reduces postprandial glucose levels, and reduces bodyweight in patients with diabetes using mealtime insulin. SYMLIN® (pramlintide acetate) is indicated for patients with type 1 or type 2 diabetes who use mealtime insulin and have failed to achieve desired glycemic control despite optimal insulin therapy.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
SYMLIN

Approved Use

SYMLIN is indicated as an adjunctive treatment in patients with type 1 or type 2 diabetes who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy.

Launch Date

2005

Sample Use Guides

•Upon initiation of SYMLIN® (pramlintide acetate), reduce mealtime insulin dose by 50%. Monitor glucoses frequently and individualize subsequent insulin dose adjustments. •Type 1 Diabetes: Start at 15 mcg subcutaneously before major meals. Increase in 15 mcg increments to a maximum premeal dose of 30 or 60 mcg; if not tolerated, reduce to 30 mcg, as tolerated. •Type 2 Diabetes: Start at 60 mcg subcutaneously before major meals then increase to 120 mcg before meals, as tolerated. •Wait at least 3 days between dose titrations to minimize nausea.
Route of Administration: Other
Name Type Language
PRAMLINTIDE ACETATE
MART.   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
PRAMLINTIDE ACETATE [ORANGE BOOK]
Common Name English
AC0-137
Code English
PRAMLINTIDE ACETATE HYDRATE
Common Name English
PRAMLINTIDE ACETATE [MART.]
Common Name English
SYMLIN
Brand Name English
Pramlintide acetate [WHO-DD]
Common Name English
TRIPRO-AMYLIN ACETATE HYDRATE
Common Name English
PRAMLINTIDE ACETATE [USAN]
Common Name English
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-PRO-ILE-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2 ACETATE HYDRATE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29711
Created by admin on Sat Dec 16 00:24:18 GMT 2023 , Edited by admin on Sat Dec 16 00:24:18 GMT 2023
Code System Code Type Description
RXCUI
356773
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PRIMARY RxNorm
DRUG BANK
DBSALT000144
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PRIMARY
ChEMBL
CHEMBL1201669
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PRIMARY
EVMPD
SUB12564MIG
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PRIMARY
DAILYMED
726I6TE06G
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PRIMARY
WIKIPEDIA
Pramlintide acetate
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PRIMARY
NCI_THESAURUS
C61902
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PRIMARY
FDA UNII
726I6TE06G
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PRIMARY
PUBCHEM
71306803
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PRIMARY
USAN
JJ-102
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PRIMARY
CAS
196078-30-5
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PRIMARY