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Details

Stereochemistry ACHIRAL
Molecular Formula C7H10N2OS
Molecular Weight 170.232
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROPYLTHIOURACIL

SMILES

CCCC1=CC(=O)NC(=S)N1

InChI

InChIKey=KNAHARQHSZJURB-UHFFFAOYSA-N
InChI=1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)

HIDE SMILES / InChI

Description

Propylthiouracil is thyroid peroxidase inhibitor used to treat hyperthyroidism, which includes hyperthyroidism due to Graves' disease and toxic multinodular goiter. Propylthiouracil is used to ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy in patients who are intolerant of methimazole.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
3.38 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROPYLTHIOURACIL

Cmax

ValueDoseCo-administeredAnalytePopulation
1.62 mg/L
50 mg single, oral
PROPYLTHIOURACIL plasma
Homo sapiens

AUC

ValueDoseCo-administeredAnalytePopulation
4.19 mg × h/L
50 mg single, oral
PROPYLTHIOURACIL plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
1.22 h
50 mg single, oral
PROPYLTHIOURACIL plasma
Homo sapiens

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
Propylthiouracil is administered orally. The total daily dosage is usually given in 3 equal doses at approximately 8 hour intervals. The initial dose in adults is 300 mg daily. In patients with severe hyperthyroidism, very large goiters, or both, the initial dose may be increased to 400 mg daily; an occasional patient will require 600 to 900 mg daily initially. The usual maintenance dose is 100 to 150 mg daily.
Route of Administration: Oral
In Vitro Use Guide
Thyroid peroxidase activity was measured by monitoring the formation of resorufin from the oxidation of Amplex Red.Assay mixtures (100 uL) contained 50 mM sodium phosphate buffer, pH 7.4, 150 mM NaCl, 2 uM H2O2, 30 uM Amplex Red, 1 mM diethylenetriaminepentaacetic acid, and 2% DMSO. The reactions were initiated by the addition of TPO. Reaction mixtures to determine the background reaction rate consisted of all assay components and 4 uL of 500 unit/mL bovine catalase in 50 mM potassium phosphate buffer, pH 7.0. The background rate was subtracted from each reaction progress curve. IC50 for propylthiouracil was 3.38 uM.