ZUCLOPENTHIXOL HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H25ClN2OS.2ClH
Molecular Weight	473.887
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of ZUCLOPENTHIXOL HYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.OCCN1CCN(CC\C=C2\C3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3)CC1

InChI

InChIKey=LPWNZMIBFHMYMX-MHKBYHAFSA-N

InChI=1S/C22H25ClN2OS.2ClH/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26;;/h1-2,4-8,16,26H,3,9-15H2;2*1H/b18-5-;;

HIDE SMILES / InChI

Description
Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf
Curator's Comment: Description was created based on several sources, including https://www.lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26624987

Zuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness. Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors. Zuclopenthixol also has high affinity for α1-adrenergic and 5-HT2 receptors. Zuclopenthixol (CLOPIXOL®) is avavilable in the form of tablets and solution for intramuscular injections.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf	Antagonist 2778
Dopamine D1 receptor 101 Target ID: CHEMBL2056 Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf	Antagonist 2778
Adrenergic receptor alpha-1 169 Target ID: CHEMBL2094251 Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf	Antagonist 2778
Serotonin 2 (5-HT2) receptor 87 Target ID: CHEMBL2093870 Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schizophrenia 298 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26624987 http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf https://www.lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf	Primary		Approved 8429	CLOPIXOL Approved Use Zuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness.
Bipolar disorder, manic phase 6 Sources: http://www.lundbeck.com/upload/ca/en/files/pdf/pm/Clopixol.pdf https://www.lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf	Primary		Approved 8429	CLOPIXOL Approved Use Zuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness.

PubMed

Title	Date	PubMed
Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime.	1987 Jan	3651662
Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia.	1991 Dec	1822319
Clozapine and weight gain.	2001 May	11329412
Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder.	2014 May 15	24582773

Patents

Sample Use Guides

In Vivo Use Guide

Clopixol tablets: The usual dose is 10 to 50 mg per day. Clopixol Acuphase injection: The usual dose is 50 to 150 mg (1 to 3 mL) every 2 to 3 days or as instructed by your doctor. Clopixol Depot injection: The usual dose is 200 to 400 mg (1 to 2 mL) every second to fourth week.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

ZUCLOPENTHIXOL HYDROCHLORIDE

Common Name

English

Zuclopenthixol hydrochloride [WHO-DD]

Common Name

English

NSC-329015

Code

English

CLOPENTHIXOL CIS(Z)-FORM DIHYDROCHLORIDE [MI]

Common Name

English

ZUCLOPENTHIXOL DIHYDROCHLORIDE

Common Name

English

ZUCLOPENTHIXOL HYDROCHLORIDE [MART.]

Common Name

English

CLOPENTHIXOL CIS(Z)-FORM DIHYDROCHLORIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710