MESPIPERONE C-11

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H28FN3O2
Molecular Weight	408.4972
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[11CH3]N1CN(C2=CC=CC=C2)C3(CCN(CCCC(=O)C4=CC=C(F)C=C4)CC3)C1=O

InChI

InChIKey=QHJLPOSPWKZACG-BJUDXGSMSA-N

InChI=1S/C24H28FN3O2/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19/h2-4,6-7,9-12H,5,8,13-18H2,1H3/i1-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/books/NBK23614/ | https://www.ncbi.nlm.nih.gov/pubmed/7909948

Mespiperone C-11 (3-N-[11C] methylspiperone) is a radiolabeled 3-N-methylspiperone. 3-N-methylspiperone is high-affinity D2/3 dopamine and 5-HT2A serotonin receptor antagonist. It has been studied as a positron emission tomography (PET) tracer for imaging D2/3 and 5HT2A receptor densities.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2966245	Binding Agent 1064		0.097 nM [Kd]
Dopamine D3 receptor 91 Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24848155	Binding Agent 1064		0.265 nM [Kd]

PubMed

Title	Date	PubMed
Effects of age on dopamine and serotonin receptors measured by positron tomography in the living human brain.	1984 Dec 21	6334363
Radiolabeled drugs as probes of central nervous system neurons.	1985 Sep	2992842
Dopamine D2 receptor density estimates in schizophrenia: a positron emission tomography study with 11C-N-methylspiperone.	1993 Dec	7909948
Bringing New PET drugs to clinical practice - a regulatory perspective.	2013 Nov 1	24312157

Sample Use Guides

In Vivo Use Guide

intravenous injection of 20 mCi mespiperone C-11

Route of Administration: Intravenous

Name

Type

Language

MESPIPERONE C-11

Common Name

English

MESPIPERONE C 11 [USP IMPURITY]

Common Name

English

1,3,8-TRIAZASPIRO(4.5)DECAN-4-ONE, 8-(4-(4-FLUOROPHENYL)-4-OXOBUTYL)-3-(METHYL-11C)-1-PHENYL-

Common Name

English

CARBON (11C) MESPIPERONE

Common Name

English

8-(3-(P-FLUOROBENZOYL)PROPYL)-3-(11C)METHYL-1-PHENYL-1,3,8-TRIAZASPIRO(4.5)DECAN-4-ONE

Common Name

English

MESPIPERONE (11C)

Official Name

English

MESPIPERONE C 11

Official Name

English

MESPIPERONE C 11 [USAN]

Common Name

English

mespiperone (¹¹C) [INN]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID70240810