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Details

Stereochemistry ACHIRAL
Molecular Formula C24H28FN3O2
Molecular Weight 408.4972
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MESPIPERONE C-11

SMILES

[11CH3]N1CN(C2=CC=CC=C2)C3(CCN(CCCC(=O)C4=CC=C(F)C=C4)CC3)C1=O

InChI

InChIKey=QHJLPOSPWKZACG-BJUDXGSMSA-N
InChI=1S/C24H28FN3O2/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19/h2-4,6-7,9-12H,5,8,13-18H2,1H3/i1-1

HIDE SMILES / InChI
Mespiperone C-11 (3-N-[11C] methylspiperone) is a radiolabeled 3-N-methylspiperone. 3-N-methylspiperone is high-affinity D2/3 dopamine and 5-HT2A serotonin receptor antagonist. It has been studied as a positron emission tomography (PET) tracer for imaging D2/3 and 5HT2A receptor densities.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.097 nM [Kd]
0.265 nM [Kd]
PubMed

PubMed

TitleDatePubMed
Name Type Language
MESPIPERONE C-11
Common Name English
MESPIPERONE C 11 [USP IMPURITY]
Common Name English
1,3,8-TRIAZASPIRO(4.5)DECAN-4-ONE, 8-(4-(4-FLUOROPHENYL)-4-OXOBUTYL)-3-(METHYL-11C)-1-PHENYL-
Common Name English
CARBON (11C) MESPIPERONE
Common Name English
8-(3-(P-FLUOROBENZOYL)PROPYL)-3-(11C)METHYL-1-PHENYL-1,3,8-TRIAZASPIRO(4.5)DECAN-4-ONE
Common Name English
MESPIPERONE (11C)
INN  
INN  
Official Name English
MESPIPERONE C 11
USAN   USP  
USAN  
Official Name English
MESPIPERONE C 11 [USAN]
Common Name English
mespiperone (¹¹C) [INN]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID70240810
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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EVMPD
SUB08787MIG
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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USAN
II-93
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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FDA UNII
703G4LHV4V
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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CAS
94153-50-1
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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ChEMBL
CHEMBL267932
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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INN
7642
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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PUBCHEM
449759
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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NCI_THESAURUS
C175127
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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SMS_ID
100000092590
Created by admin on Sat Dec 16 16:54:59 GMT 2023 , Edited by admin on Sat Dec 16 16:54:59 GMT 2023
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