HEXACYCLONATE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H15O3.Na
Molecular Weight	194.2034
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OCC1(CC([O-])=O)CCCCC1

InChI

InChIKey=YPKROQTVZNJPNX-UHFFFAOYSA-M

InChI=1S/C9H16O3.Na/c10-7-9(6-8(11)12)4-2-1-3-5-9;/h10H,1-7H2,(H,11,12);/q;+1/p-1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7933781 | https://www.ncbi.nlm.nih.gov/pubmed/1307777

Hexacyclonic Acid (aka gevilon) has been clinically demonstrated to produce hypolipidemic effects. It has been investigated as a treatment for coronary heart disease, and hypertensive disease with severe lipid metabolic disturbances. Gevilon has been found to have a hypolipidemic effect in reducing the levels of total cholesterol, beta-cholesterol, triglycerides, increasing alpha-cholesterol levels and normalizing the atherogenicity coefficient; especially in patients with Type IIb dyslipoproteinemia.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperlipoproteinemia 9 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1307777	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Sodium hexacyclonate as coadjuvant in the treatment and rehabilitation of the chronic alcoholic].	1961 Jun 20	13692926

Patents

Sample Use Guides

In Vivo Use Guide

Patients with hyperlipoproteinemia were divided according to hyperlipoproteinemia type IIA, IIB, and IV. After one month of isocaloric diet, the patients were given a single night gevilon dose of 900 mg for a period of 3 months. In all groups increased levels of cholesterol, beta-lipoproteins and triglycerides were significantly reduced after 3 months of gevilon treatment. In all patients, the HDL/LDL ratio increased close to normal values.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

HEXACYCLONATE SODIUM

Common Name

English

SODIUM 1-(HYDROXYMETHYL)CYCLOHEXANEACETATE

Systematic Name

English

1-(HYDROXYMETHYL)CYCLOHEXANEACETATE SODIUM SALT

Common Name

English

HEXACYCLONATE SODIUM [MI]

Common Name

English

SODIUM HEXACYCLONATE

Official Name

English

sodium hexacyclonate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47795