DROCINONIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H35FO6
Molecular Weight	438.5295
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)CO

InChI

InChIKey=GZBONOYGBJSTHF-QLRNAMTQSA-N

InChI=1S/C24H35FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h13,15-17,19,26,28H,5-12H2,1-4H3/t13-,15-,16-,17-,19+,21-,22-,23-,24+/m0/s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/508182 | https://www.ncbi.nlm.nih.gov/pubmed/1185572 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 471, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Drocinonide is a synthetic glucocorticoid used as anti-inflammatory agent. It was shown that drocinonide phosphate potassium is effective ocular anti-inflammatory agent that does not show a strong tendency to elevate the intra-ocular pressure. Drocinonide phosphate potassium forms an insoluble complex with neomycin sulfate in aqueous solution. Dibasic sodium phosphate can be employed in an ophthalmic formulation to prevent the formation of this precipitate without affecting the stability of the steroid or the bioactivity of the antibiotic.

Approval Year

PubMed

Title	Date	PubMed
Stabilizing effect of inorganic phosphate salts on antibiotic-steroid ophthalmic preparations.	1975 Sep	1185572
Intraocular pressure response to topically administered fluorometholone.	1979 Nov	508182

Patents

Name

Type

Language

DROCINONIDE

Official Name

English

TETRAHYDROTRIAMCINOLONE ACETONIDE

Common Name

English

DROCINONIDE [USAN]

Common Name

English

PREGNANE-3,20-DIONE, 9-FLUORO-11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (5.ALPHA.,11.BETA.,16.ALPHA.)-

Common Name

English

drocinonide [INN]

Common Name

English

9-Fluoro-11β,16α,17,21-tetrahydroxy-5α-pregnane-3,20-dione cyclic 16,17-acetal with acetone

Common Name

English

Code System Code Type Description

WIKIPEDIA

Drocinonide