U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Dalazatide is a 37-amino acid synthetic peptide, a derivative of ShK, which was originally isolated from the venom of the Carribean Sea Anemone. The drug was first discovered by the University of California at Irvine and further developed by Kineta and KPI Therapeutics. Dazalatide is a specific inhibitor of the voltage-gated Kv1.3 potassium channel. The Kv1.3 potassium channel is highly upregulated on effector memory T-cells (TEM cells), and is involved in regulating their calcium uptake. Chronically activated memory T cells are key mediators of numerous autoimmune diseases, including psoriasis and multiple sclerosis. In vivo studies with dalazatide in a delayed-type hypersensitivity (DTH) model have shown that drug treatment inhibited the DTH response by suppressing TEM cells, but had no effect on naïve or central memory T cells. Dalazatide was investigated in a phase I clinical trials for the treatment of plaque psoriasis. The study indicates that dalazatide is generally well tolerated and can improve psoriatic skin lesions by modulating T cell surface and activation marker expression and inhibiting mediators of inflammation in the blood.

Approval Year

Name Type Language
DALAZATIDE
INN  
Official Name English
SHK186
Code English
O-PHOSPHONO-L-TYROSYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL(POTASSIUM CHANNEL TOXIN KAPPA-STICHOTOXIN-SHELA STOICHACTIS HELIANTHUS (CARIBBEAN SEA ANEMONE)) PEPTIDAMIDE
Common Name English
Dalazatide [WHO-DD]
Common Name English
SHK-186
Code English
dalazatide [INN]
Common Name English
Code System Code Type Description
CAS
1081110-69-1
Created by admin on Sat Dec 16 09:09:43 GMT 2023 , Edited by admin on Sat Dec 16 09:09:43 GMT 2023
PRIMARY
NCI_THESAURUS
C166962
Created by admin on Sat Dec 16 09:09:43 GMT 2023 , Edited by admin on Sat Dec 16 09:09:43 GMT 2023
PRIMARY
PUBCHEM
86278334
Created by admin on Sat Dec 16 09:09:43 GMT 2023 , Edited by admin on Sat Dec 16 09:09:43 GMT 2023
PRIMARY
INN
9995
Created by admin on Sat Dec 16 09:09:43 GMT 2023 , Edited by admin on Sat Dec 16 09:09:43 GMT 2023
PRIMARY
FDA UNII
6U0259J807
Created by admin on Sat Dec 16 09:09:43 GMT 2023 , Edited by admin on Sat Dec 16 09:09:43 GMT 2023
PRIMARY