Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H16N2O3S |
Molecular Weight | 244.3121 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CCC(=O)O)C[C@@]1([H])[C@]2([H])[C@]([H])(CS1)N=C(N2)O
InChI
InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
DescriptionSources: www.ncbi.nlm.nih.gov/pubmed/18356320Curator's Comment:: description was created based on several sources, including
www.ncbi.nlm.nih.gov/pubmed/17182796,
www.ncbi.nlm.nih.gov/pubmed/19056639
Sources: www.ncbi.nlm.nih.gov/pubmed/18356320
Curator's Comment:: description was created based on several sources, including
www.ncbi.nlm.nih.gov/pubmed/17182796,
www.ncbi.nlm.nih.gov/pubmed/19056639
Biotin (also known as vitamin H and vitamin B7) is a water-soluble vitamin which is required for normal cellular functions, growth and development. Biotin is an important cofactor for many mitochondria and cytoplasm enzymes: acetyl-CoA carboxylase a (ACCa),7 ACCb, pyruvate carboxylase (PC), propionyl-CoA carboxylase (PCC), and methylcrotonyl-CoA carboxylase (MCC) and plays critical role in in the intermediate metabolism of gluconeogenesis, fatty acid synthesis, and amino acid catabolism. The vitamin cannot be synthesized by humans and must be obtained from diet. If there is a lack of biotin, an organism starts suffering from biotin deficiency, a condition which is very common among pregnant women, for example. The vitamin deficiency effects hair, nail growth and skin health. For preventing measures, biotin should be taken as a dietary supplement (in a form of vitamin complex or as a pure biotin) which are marketed worldwide under different names. Biotin is a part of many formulations which were approved by FDA.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3098919
Curator's Comment:: Biotin was shown to cross the blood brain barrier in rats.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Preventing | INFUVITE ADULT Approved UseINFUVITE ADULT is a combination of vitamins indicated for prevention of vitamin deficiency in adults and children aged 11 and older receiving parenteral nutrition. Launch Date9.5852161E11 |
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Preventing | BIOTIN Approved UseAs a dietary supplement. |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
508.5 ng/mL |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
84.8 ng/mL |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
494.9 ng/mL |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
823.8 ng/mL |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
214.6 ng/mL |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
184 ng/mL |
20 mg 1 times / day steady-state, oral dose: 20 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
41 ng/mL |
5 mg 1 times / day steady-state, oral dose: 5 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
91 ng/mL |
10 mg 1 times / day steady-state, oral dose: 10 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1652.4 ng × h/mL |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
210 ng × h/mL |
10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
|
2315 ng × h/mL |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
4010 ng × h/mL |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
605.1 ng × h/mL |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
15 h |
20 mg 1 times / day steady-state, oral dose: 20 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
15 h |
5 mg 1 times / day steady-state, oral dose: 5 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
15 h |
10 mg 1 times / day steady-state, oral dose: 10 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
BIOTIN serum | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
81% |
100 mg single, oral dose: 100 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
|
81% |
300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered: |
BIOTIN plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED |
PubMed
Title | Date | PubMed |
---|---|---|
[Development and identification of T. aestivum-S. cereale-H. villosa double translocation line 1RS.1BL, 6VS.6AL via chromosome C-banding and dual color FISH]. | 2001 |
|
Intra- and inter-areal connections between the primary visual cortex V1 and the area immediately surrounding V1 in the rat. | 2001 |
|
Immunohistochemistry of MMPs and TIMPs. | 2001 |
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Amplification methods for the immunolocalization of rare molecules in cells and tissues. | 2001 |
|
A new quantitative analytical method of serum biotinidase activity using biocytin as a substrate and its clinical significance in Japan. | 2001 Apr |
|
Avidin expression during chick chondrocyte and myoblast development in vitro and in vivo: regulation of cell proliferation. | 2001 Apr |
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Neurotrophic actions of novel compounds designed from cyclopentenone prostaglandins. | 2001 Apr |
|
Optical measurement of transverse molecular diffusion in a microchannel. | 2001 Apr |
|
Progress towards single-molecule sequencing: enzymatic synthesis of nucleotide-specifically labeled DNA. | 2001 Apr 13 |
|
Polymer support for exonucleolytic sequencing. | 2001 Apr 13 |
|
Mu-opioid receptors are present in functionally identified sympathoexcitatory neurons in the rat rostral ventrolateral medulla. | 2001 Apr 23 |
|
The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits. | 2001 Feb |
|
Effects of supplemental dietary biotin on performance of Holstein cows during early lactation. | 2001 Feb |
|
Reconstruction of the transected cat spinal cord following NeuroGel implantation: axonal tracing, immunohistochemical and ultrastructural studies. | 2001 Feb |
|
Axon trajectories in local circuits of the primary motor cortex in the macaque monkey (Macaca fuscata). | 2001 Feb |
|
An in situ hybridization protocol to detect rare mRNA expressed in neural tissue using biotin-labelled oligonucleotide probes. | 2001 Feb |
|
Longitudinal study of anti-Candida albicans mucosal immunity against aspartic proteinases in HIV-infected patients. | 2001 Feb 1 |
|
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. | 2001 Feb 1 |
|
Relationship between serum biotin concentration and moisture content of the sole horn in cows with clinical laminitis or sound hooves. | 2001 Feb 17 |
|
Screening effect of PEG on avidin binding to liposome surface receptors. | 2001 Feb 19 |
|
Combined laser tweezers and dielectric field cage for the analysis of receptor-ligand interactions on single cells. | 2001 Jan |
|
Azospirillum doebereinerae sp. nov., a nitrogen-fixing bacterium associated with the C4-grass Miscanthus. | 2001 Jan |
|
Postnatal development of biotinylated dextran amine-labeled corpus callosum axons projecting from the visual and auditory cortices to the visual cortex of the rat. | 2001 Jan |
|
Thalamocortical arbors extend beyond single cortical barrels: an in vivo intracellular tracing study in rat. | 2001 Jan |
|
Enhanced surface plasmon resonance immunosensing using a streptavidin-biotinylated protein complex. | 2001 Jan |
|
Liposomes labeled with biotin and horseradish peroxidase: a probe for the enhanced amplification of antigen--antibody or oligonucleotide--DNA sensing processes by the precipitation of an insoluble product on electrodes. | 2001 Jan 1 |
|
Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder. | 2001 Jan 15 |
|
Expression sequence tag-specific full-length cDNA cloning: actin cDNAs. | 2001 Jan 24 |
|
Avidin-biotin-immobilized liposome column for chromatographic fluorescence on-line analysis of solute-membrane interactions. | 2001 Jan 5 |
|
Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. | 2001 Jun 1 |
|
Functional signal peptides bind a soluble N-terminal fragment of SecA and inhibit its ATPase activity. | 2001 Jun 1 |
|
Structural characterization of pyrrolic cross-links in collagen using a biotinylated Ehrlich's reagent. | 2001 Jun 1 |
|
Abnormal thiol reactivity of tropomyosin in essential hypertension and its association with abnormal sodium-lithium countertransport kinetics. | 2001 Mar |
|
Neuroendocrine differentiation in bronchial carcinomas of classic squamous-cell type: an immunohistochemical study of 29 cases applying the tyramide signal amplification technique. | 2001 Mar |
|
In situ hybridization detection of calcitonin mRNA in routinely fixed, paraffin-embedded tissue sections: a comparison of different types of probes combined with tyramide signal amplification. | 2001 Mar |
|
Stimulation of corticospinal tract regeneration in the chronically injured spinal cord. | 2001 Mar |
|
PCR-ELISAs for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples. | 2001 Mar |
|
Synthesis and application of circularizable ligation probes. | 2001 Mar |
|
Investigating the surface expression of the renal type IIa Na+/Pi-cotransporter in Xenopus laevis oocytes. | 2001 Mar 1 |
|
Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. | 2001 Mar 1 |
|
Single epitope multiple staining to detect ultralow frequency B cells. | 2001 Mar 1 |
|
Propagation of synchronous epileptiform events from subiculum backward into area CA1 of rat brain slices. | 2001 Mar 23 |
|
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. | 2001 Mar 5 |
|
Alginate, a bioresorbable material derived from brown seaweed, enhances elongation of amputated axons of spinal cord in infant rats. | 2001 Mar 5 |
|
Cloning and characterization of biotin biosynthetic genes of Kurthia sp. | 2001 Mar 7 |
|
Metabolic biotinylation of secreted and cell surface proteins from mammalian cells. | 2001 Mar 9 |
|
Sodium ion-translocating decarboxylases. | 2001 May 1 |
|
Adsorption of avidin on microfabricated surfaces for protein biochip applications. | 2001 May 20 |
|
Rotation of a complex of the gamma subunit and c ring of Escherichia coli ATP synthase. The rotor and stator are interchangeable. | 2001 May 4 |
|
Immobilization of sugar-non-specific nucleases by utilizing the streptavidin--biotin interaction. | 2001 May 4 |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment:: https://cscprivatelabel.com/wp-content/uploads/2016/05/Biotin.pdf
Recommended daily dosage is 10 ml (in a form of infuvite adult) or 1 tablet a day in a form of Biotin dietary supplement (the dosage may vary).
Route of Administration:
Other
Human T lymphoma Jurkat cells and monocytic myeloid U937 cells were incubated with different concentrations of biotin (nM): 0.025, 0.25 and 10, representing plasma levels in biotin-deficient, biotin-sufficient and biotin-supplemented adults. When taken together with folate, biotin synergizes in the repression of pro-inflammatory cytokines and long-terminal repeats (LTRs), mediated by interactions between HLCS and other chromatin proteins.
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Classification Tree | Code System | Code | ||
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DSLD |
2669 (Number of products:7171)
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WHO-VATC |
QA11HA05
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FDA ORPHAN DRUG |
760720
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LOINC |
34398-8
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LIVERTOX |
107
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LOINC |
31997-0
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DSLD |
22 (Number of products:127)
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WHO-ATC |
A11HA05
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NCI_THESAURUS |
C45812
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LOINC |
1980-2
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SUB32335
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346
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373
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200-399-3
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58-85-5
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6SO6U10H04
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58-85-5
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1203
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CHEMBL857
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M2506
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PRIMARY | Merck Index | ||
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BIOTIN
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1588
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SUB05841MIG
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171548
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D001710
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C309
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DB00121
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1071508
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PRIMARY | USP-RS | ||
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314583
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ALTERNATIVE |
ACTIVE MOIETY