Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C47H80O17 |
| Molecular Weight | 917.1279 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 24 / 24 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CO[C@H]1C[C@@H](O[C@H]2C[C@@H](O[C@H]2[C@]3(C)CC[C@@H](O3)[C@]4(C)CC[C@]5(C[C@H](O)[C@@H](C)[C@H](O5)[C@@H](C)[C@@H]6O[C@](O)(CC(O)=O)[C@@H](C)[C@H](OC)[C@H]6OC)O4)[C@H]7O[C@](C)(O)[C@H](C)C[C@@H]7C)O[C@@H](C)[C@@H]1OC
InChI
InChIKey=RWVUEZAROXKXRT-VQLSFVLHSA-N
InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+/m0/s1
Maduramicin is antibiotic isolated from actinobacteria Actinomadura rubra. Maduramicin is used in veterinary as an aid in the prevention of coccidiosis in broiler chickens and turkeys. The compound is reported to be toxic to animals and humans if improperly used or by accident, resulting in heart failure, skeletal muscle degeneration, and even death. Studies have shown that toxicity is due to activation of protein phosphatase 2A, and the manipulation of the ROS-PTEN-Akt-Erk1/2 pathway may be a potential approach to prevent maduramicin -induced cardiotoxicity.
Approval Year
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79356-08-4
Created by
admin on Mon Mar 31 22:00:04 GMT 2025 , Edited by admin on Mon Mar 31 22:00:04 GMT 2025
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DTXSID001044546
Created by
admin on Mon Mar 31 22:00:04 GMT 2025 , Edited by admin on Mon Mar 31 22:00:04 GMT 2025
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196129
Created by
admin on Mon Mar 31 22:00:04 GMT 2025 , Edited by admin on Mon Mar 31 22:00:04 GMT 2025
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6S6GVE3CIQ
Created by
admin on Mon Mar 31 22:00:04 GMT 2025 , Edited by admin on Mon Mar 31 22:00:04 GMT 2025
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
