U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C9H15NO.ClH
Molecular Weight 189.682
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PSEUDOPELLETIERINE HYDROCHLORIDE

SMILES

Cl.CN1[C@H]2CCC[C@@H]1CC(=O)C2

InChI

InChIKey=CVGRGXQEVKWHHS-KVZVIFLMSA-N
InChI=1S/C9H15NO.ClH/c1-10-7-3-2-4-8(10)6-9(11)5-7;/h7-8H,2-6H2,1H3;1H/t7-,8+;

HIDE SMILES / InChI

Description

Pseudopelletierine is the main alkaloid derived from the root-bark of the pomegranate tree (Punica granatum). Pseudopelletierine is used as an enzyme substrate.

Originator

Tanret, C.
6

Approval Year

Unknown
139,594

Targets

Primary TargetPharmacologyConditionPotency
amyloid beta-protein (1-40)
3
Binding Agent
1,064

Conditions

ConditionModalityTargetsHighest PhaseProduct
Alzheimer’s disease
272
 Primary
Basic research
Unknown

PubMed

Patents

US2715147
3
US3184467
3
US3544578
3

Sample Use Guides

In Vivo Use Guide
Guinea pig: LDLo - subcutaneous, 230 mg/kg
Route of Administration: Other
In Vitro Use Guide
Binding to Abeta(1-40) of pseudopelletierine was (0.57 x 10(8) M(-1)
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966